Polyomavirus-associated nephropathy in renal transplantation: critical issues of screening and management

Advances in Experimental Medicine and Biology
Hans H HirschEmilio Ramos

Abstract

Polyomavirus-associated nephropathy (PVAN) is an emerging disease in renal transplant patients with variable prevalence of 1-10% and graft loss up to 80%. BK virus (BKV) is the primary etiologic agent, but JC virus (JCV) and possibly simian virus SV40 may account for some cases. Intense immunosuppression is viewed as the most important risk factor. However, the preferential manifestation in renal transplants as compared to other allografts or to autologous kidneys of other organ transplants suggests that organ determinants and immunologic factors synergize: Renal tubular epithelial cells and their compensatory proliferation to restore tubular integrity after immunologic, ischemic or toxic injury may provide the critical cellular milieu supporting polyomavirus replication while immune control is impaired due to maintenance immunosuppression, anti-rejection treatment and HLA-mismatches. Patient determinants (older age, male gender, seronegative recipient), and viral factors (genotype, serotype) may have a contributory role. The definitive diagnosis of PVAN requires allograft biopsy which is, however, challenged by (i) limited sensitivity due to (multi-)focal involvement (sampling errors); (ii) varying presentations with cytopathi...Continue Reading

Citations

Dec 21, 2007·The New England Journal of Medicine·Jay A Fishman
Mar 5, 2009·Antimicrobial Agents and Chemotherapy·Margot BrickelmaierLeonid Gorelik
Jan 26, 2008·Emerging Infectious Diseases·Tae Hee HanEung-Soo Hwang
Apr 23, 2013·Clinical & Developmental Immunology·Michela CioniHans H Hirsch
Apr 13, 2013·Memórias do Instituto Oswaldo Cruz·Fernando Assis Ferreira MeloAntonio Carlos Rosário Vallinoto
Mar 16, 2017·Transplant International : Official Journal of the European Society for Organ Transplantation·Neerja AgrawalMichelle A Josephson
Dec 6, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kathryn J WigginsRobyn G Langham
Mar 30, 2017·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Herman F WunderinkMariet C W Feltkamp
Aug 15, 2017·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Chitimaporn JanphramPorpon Rotjanapan
Jun 3, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H F WunderinkM C W Feltkamp
Nov 21, 2007·Journal of Cellular Physiology·Kamel KhaliliMahmut Safak
Nov 26, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Muna SalamaPaolo Ferrari
Feb 20, 2019·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Zakaria E ZakariaTorki Al-Otaibi
Jul 25, 2009·Diagnostic Cytopathology·David CimbalukPaolo Gattuso
Jan 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H H HirschUNKNOWN AST Infectious Diseases Community of Practice
Jul 27, 2018·Transplantation·Herman F WunderinkMariet C W Feltkamp
Jun 19, 2010·Transplantation·Nicolas PalletChristophe Legendre
Mar 13, 2019·Clinical Transplantation·Hans H HirschUNKNOWN AST Infectious Diseases Community of Practice
Sep 25, 2008·Transplant Infectious Disease : an Official Journal of the Transplantation Society·M KoukoulakiS Drakopoulos
Aug 7, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·N KamarL Rostaing
Dec 17, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Vikas R DharnidharkaCarlos E Araya
Mar 15, 2015·Transplantation·Brian J NankivellRaghwa N Sharma
Jun 1, 2007·Clinical and Vaccine Immunology : CVI·David LeuenbergerHans H Hirsch
Jun 1, 2011·Cancer·Sonia RamamoorthyJohn M Carethers
May 31, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Y J LiY C Tian
Jun 20, 2012·Journal of Medical Virology·Gloria B McClureJohn A Vanchiere
May 9, 2015·Journal of Medical Virology·Hanen BoukoumMahjoub Aouni
Jul 29, 2015·Transplant Infectious Disease : an Official Journal of the Transplantation Society·S QueridoD Machado
Mar 5, 2013·The Medical Journal of Australia·Bruce J BrewEugene O Major
Sep 12, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M DziubianauN Babel
May 26, 2018·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Gabriel Godinho PintoAlessandro C Pasqualotto
Apr 6, 2019·Open Forum Infectious Diseases·H F WunderinkM C W Feltkamp
Apr 14, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Jack AguilarJon Kobashigawa
Jun 30, 2009·Wiener klinische Wochenschrift·Michael HaidingerGeorg A Böhmig
Feb 12, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Jesse D ScholdHerwig-Ulf Meier-Kriesche
Jul 7, 2012·Clinical Transplantation·Kazuaki YamanakaYasuji Ichikawa
Aug 9, 2016·Annual Review of Virology·Michael J Imperiale, Mengxi Jiang

❮ Previous
Next ❯

Related Concepts

Related Feeds

BK Virus Infection

BK virus infection is a significant complication of modern immunosuppression used in kidney transplantation. Discover the latest research on BK virus infection here.

© 2022 Meta ULC. All rights reserved