Polyostotic osteonecrosis in a patient with celiac disease.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
L Agrawal

Abstract

To emphasize the role of history and physical examination in the clinical evaluation of hypocalcemia and to describe a patient with celiac sprue and multiple osteonecrosis, a previously unrecognized association. A case report is presented of a 39-year-old man with mild hypocalcemia, diarrhea, and arthralgias, and the appropriate clinical and laboratory assessment for these complaints is outlined. Secondary hyperparathyroidism, celiac sprue, and extensive osteonecrosis were detected by hematologic and radiologic studies. The hematologic variables normalized after institution of a gluten-free diet and calcium supplementation. This is the first report of celiac sprue and osteonecrosis in one patient. A possible causal relationship due to secondary hyperparathyroidism is suggested, and alternative explanations are discussed.

References

May 28, 1992·The New England Journal of Medicine·H J Mankin
Oct 1, 1990·Journal of Internal Medicine·R Paul
Feb 1, 1972·Gut·W F DoeC C Booth
Jan 1, 1981·Gut·S MeyersH D Janowitz
Aug 1, 1993·Seminars in Arthritis and Rheumatism·C C ChangM E Gershwin
Feb 1, 1994·Gut·J R Walters

❮ Previous
Next ❯

Citations

Apr 11, 2009·Rheumatology International·Alia Mohamed AtallahMohamed A Ghoneim
Feb 13, 2001·British Journal of Haematology·O RingdénUNKNOWN Acute Leukaemia Working Party of the European Group for Blood and Marrow Transplantation

❮ Previous
Next ❯

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.