Polyoxalate nanoparticles as a biodegradable and biocompatible drug delivery vehicle

Biomacromolecules
Seho KimDongwon Lee

Abstract

One of major challenges in the drug delivery lies in the development of nanoparticles that are effectively delivered to targeted cells and release their payload over an extended period to achieve a clinical response. In this paper, we report a new family of biocompatible and biodegradable polymer, termed polyoxalate that degrades hydrolytically into nontoxic byproducts. Polyoxalate was synthesized from a simple one-step polymerization reaction of 1,4-cyclohexanedimethanol and oxalyl chloride and had a MW of approximately 11000 Da. This polymer was designed to degrade by water hydrolysis into 1,4-cyclohexanedimethanol and oxalic acid, which can be easily removed from a body. Polyoxalate had a hydrophobic backbone and was formulated into nanoparticles with a mean diameter of 600 nm, which is suitable for drug delivery involving phagocytosis by macrophages. Polyoxalate nanoparticles were readily taken up by RAW 264.7 macrophage cells and HEK (human embryonic kidney) 293 cells and exhibited a minimal cytotoxicity in a time- and dose-dependent manner. In comparison with PLGA nanoparticles, polyoxalate nanoparticles had a significantly higher cell viability. We anticipated that the ease of synthesis and excellent biocompatibility mak...Continue Reading

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Citations

Apr 27, 2013·International Journal of Pharmaceutics·Donghyuck YooDongwon Lee
Oct 20, 2011·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Jinshun Zhao, Vincent Castranova
Jul 19, 2011·Journal of Biomedicine & Biotechnology·Rui ChenXiqun Jiang
Aug 12, 2010·Journal of Biomaterials Science. Polymer Edition·Eunyong LeeDongwon Lee
Feb 5, 2014·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Reza Azadbakht, Javad Khanabadi
Jul 25, 2012·Therapeutic Delivery·Donghyun HongDongwon Lee
Dec 11, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Licheng TanZhiping Peng
Jun 15, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Steven P SchwendemanAnna S Schwendeman
Mar 5, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kyeongyeol SeongDongwon Lee
Jun 18, 2011·Journal of Biomedical Materials Research. Part a·Yiseul SongDongwon Lee
Jul 7, 2015·Journal of Biomaterials Science. Polymer Edition·Nutthakritta PhromviyoApiwat Chompoosor
Jul 9, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·G Morral-RuízM J García-Celma
Jan 13, 2015·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Reza Azadbakht, Javad Khanabadi
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mariappan RajanMurugan A Munusamy
Jul 31, 2020·Cancer Reports·Ankur SharmaKavindra Kumar Kesari
Jul 5, 2016·Bioengineering & Translational Medicine·Jing Liang, Bin Liu
Sep 1, 2017·Advanced Biosystems·Jinqiang WangZhen Gu
Jan 14, 2021·Advanced Science·Ge-Xia WangFrederik R Wurm
Jun 3, 2021·International Journal of Molecular Sciences·Berwin Singh Swami VethaAzeez Aileru

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