Poly(oxanorbornene)-Coated CdTe Quantum Dots as Antibacterial Agents.

ACS Applied Bio Materials
Denise N WilliamsZeev Rosenzweig

Abstract

In this study, synthetic mimics of antimicrobial peptides based on poly(oxanorbornene) molecules (or PONs) were used to coat CdTe quantum dots (QDs). These PONs-CdTe QDs were investigated for their activity against Escherichia coli, a bacterium with antibiotic resistant strains. At the same time, the antibacterial activity of the PONs-CdTe QDs was compared to the antibacterial activity of free PONs and free CdTe QDs. The observed antibacterial activity of the PONs-CdTe QDs was additive and concentration dependent. The conjugates had a significantly lower minimum inhibitory concentration (MIC) than the free PONs and QDs, particularly for PONs-CdTe QDs which contained PONs of high amine density. The maximum activity of PONs-CdTe QDs was not realized by conjugating PONs with the highest intrinsic antibacterial activity (i.e., the lowest MIC in solution as free PONs), indicating that the mechanism of action for free PONs and PONs-CdTe QDs is different. Equally important, conjugating PONs to CdTe QDs decreased their hemolytic activity against red blood cells compared to free PONs, lending to higher therapeutic indices against E. coli. This could potentially enable the use of higher, and therefore more effective, PONs-QDs concentrati...Continue Reading

References

Apr 11, 2007·Bioorganic & Medicinal Chemistry Letters·Edward TurosDaniel V Lim
Apr 19, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Zhisong LuXu Yang
Jul 3, 2008·Journal of the American Chemical Society·Karen LienkampGregory N Tew
Jul 8, 2009·Nature Nanotechnology·Lihong LiuYi-Yan Yang
Oct 1, 2009·Chemistry : a European Journal·Karen LienkampGregory N Tew
Mar 13, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Maryam BanoeeAhmad R Shahverdi
Mar 19, 2011·Nanotechnology·Soonhyang ParkJay L Nadeau
Oct 28, 2011·Expert Review of Anti-infective Therapy·Adil M AllahverdiyevMiriam Rafailovich
Dec 20, 2013·International Journal of Molecular Sciences·Matthias RoessleinPeter Wick
Mar 15, 2014·Journal of the American Chemical Society·Jamee BreseeDaniel L Feldheim
Jul 2, 2014·Public Health Reports·Boris D Lushniak
Jan 19, 2016·Nature Materials·Colleen M CourtneyPrashant Nagpal
Aug 2, 2016·Lancet·Ramanan LaxminarayanJohn-Arne Røttingen
Mar 22, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Zheng ZhengZeev Rosenzweig

❮ Previous
Next ❯

Citations

Mar 14, 2021·Carbohydrate Polymers·Matin Jasli LimAnwar Usman
Sep 25, 2021·Advanced Science·Mohammad J HajipourMorteza Mahmoudi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.