Polyoxometalate incorporated polymer monolith microextraction for highly selective extraction of antidepressants in undiluted urine

Talanta
Jiao CaiYu-Qi Feng

Abstract

In this work, a polyoxometalate (POM) incorporated polymer monolith microextraction (PMME) was successfully proposed and employed in the selective extraction of basic antidepressants in undiluted urine sample. This hybrid monolith exhibited strong cation-exchange interaction (SCX) with positively charged antidepressants when pH was 3.0, because of the multiple ionizable moieties on polyanionic POM. As such, antidepressants in complex sample matrices were efficiently extracted by the monolith, and the matrix effect was significantly reduced. In addition, due to the high amount of anionic POM, the monolith exhibited remarkable extraction capacities for target antidepressants ranging from 4.7 to 5.8mg/g. Further, the POM incorporated PMME was coupled with high-performance liquid chromatography-ultraviolet (HPLC-UV). Thus, antidepressants in undiluted urine sample was efficiently extracted under optimized extraction conditions online. The limits of detection (LODs) for the target antidepressants ranged from 0.7 to 1.4ng/mL, and the linear range was 5-1000ng/mL with determination coefficients (R2) higher than 0.9960. The recoveries ranged from 86.8% to 104.0% with relative standard deviations (RSDs) of 0.4-10.1%. The proposed proced...Continue Reading

Citations

Feb 17, 2019·Journal of Separation Science·Fernando Maya, Brett Paull
Mar 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Edvaldo Vasconcelos Soares MacielFernando Mauro Lanças
Nov 10, 2020·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Tadaharu Ueda

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