Polypeptide-Conjugated Second Near-Infrared Organic Fluorophore for Image-Guided Photothermal Therapy

ACS Nano
Tuanwei LiLifeng Yan

Abstract

Image-guided photothermal therapy (PTT) is an attractive strategy to improve the diagnosis accuracy and treatment outcomes by monitoring the accumulation of photothermal agents in tumors in real-time and determining the best treatment window. Taking advantage of the superior imaging quality of NIR-II fluorescence imaging and remote-controllable phototherapy modality of PTT, we developed a facile macromolecular fluorophore (PF) by conjugating a small-molecule NIR-II fluorophore (Flav7) with an amphiphilic polypeptide. The PF can form uniform micelles in aqueous solution, which exhibit a slight negative charge. In vitro experimental results showed that the PF nanoparticles showed satisfactory photophysical properties, prominent photothermal conversion efficiency (42.3%), excellent photothermal stability, negligible cytotoxicity, and photothermal toxicity. Meanwhile, the PF can visualize and feature the tumors by NIR-II fluorescence imaging owing to prolonged blood circulation time and enhanced accumulation in tumors. Moreover, in vivo studies revealed that the PF nanoparticles achieved an excellent photothermal ablation effect on tumors with a low dose of NIR-II dye and light irradiation, and the process can be traced by NIR fluo...Continue Reading

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Citations

Mar 13, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Wenhai LinGang Han
May 27, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yuandong ZhangZhigang Xie
Jul 19, 2019·International Journal of Molecular Sciences·Maharajan SivasubramanianLeu-Wei Lo
Dec 11, 2019·Chemical Communications : Chem Comm·Kun QianZhen Cheng
Nov 7, 2019·Frontiers in Chemistry·Yizhou LiAixi Yu
Nov 17, 2020·Chemical Society Reviews·Guangxue FengDan Ding
Dec 29, 2020·International Journal of Nanomedicine·Jinghua SunRuiping Zhang
Mar 6, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hongyun QianLifeng Yan
Nov 14, 2020·Biomedical Materials·Huiping Dang, Lifeng Yan
Jun 24, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chang DuRong Zhang
Jul 27, 2021·Nano Letters·Ziqiang SunQiangbin Wang
Jul 27, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Yingying SongChang-Ming Dong
Jan 19, 2021·ACS Biomaterials Science & Engineering·Danyang XuRuichan Lv
Aug 13, 2021·Small·Hanming DaiXiaochen Dong
Aug 23, 2019·ACS Applied Materials & Interfaces·Yudong XueWeian Zhang
Aug 17, 2021·Frontiers in Chemistry·Yunguang ZhangHao Wang
Aug 14, 2020·Journal of the American Chemical Society·Chunyan LiQiangbin Wang
Sep 3, 2020·ACS Central Science·Shangfeng WangFan Zhang
Aug 19, 2020·ACS Nano·Yanfang WangGaolin Liang
Sep 15, 2021·ACS Applied Materials & Interfaces·Wenyu WangYuen Wu

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