Polypeptide growth factors augment interleukin 1-induced release of prostaglandin E2 by rheumatoid arthritis synovial cells in vitro

Cytokine
D H GoddardR Newton

Abstract

When stimulated with increasing amounts of interleukin 1 beta (IL 1 beta) rheumatoid arthritis (RA), as compared with osteoarthritis (OA), synovial cells grown in RPMI plus fetal bovine serum (FBS), released significantly more prostaglandin E2 (PGE2) (p less than 0.05; paired t test, two-tailed). PGE2 release by IL 1 beta-stimulated RA synovial cells grown for 14 days in serum-free RPMI was significantly less than that released by the same cells grown in medium plus 10% FBS (p less than 0.03; two-tailed). Since these data suggest that growth factors present in FBS may augment the effects of IL 1 beta, experiments were conducted to study the influence of four polypeptide growth factors--transforming growth factor-beta (TGF-beta), platelet-derived growth factor (PDGF), epidermal growth factor (EGF), and basic fibroblast growth factor (bFGF), on IL 1 beta-induced release of PGE2 by cultured RA synovial cells. Both EGF and bFGF significantly enhanced IL 1 beta-induced release of PGE2 (p less than 0.05; paired t test, one-tailed), while PDGF was synergistic with IL 1 beta, significantly increasing release of PGE2 by these cultured cells (p less than 0.02; two-tailed). No such effect was seen when TGF-beta was added to the culture me...Continue Reading

References

Mar 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·J M DayerD R Robinson
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R M BurchJ Axelrod
Dec 1, 1987·Cellular Immunology·R C Newton, M Covington
Mar 1, 1988·Digestive Diseases and Sciences·C A Dinarello
Sep 1, 1987·The Journal of Cell Biology·M B SpornB de Crombrugghe
Dec 1, 1987·Proceedings of the Society for Experimental Biology and Medicine·D HamermanK A Thomas
Feb 6, 1985·Nature·M B Sporn, A B Roberts
Jan 1, 1984·Annual Review of Biochemistry·R James, R A Bradshaw
Apr 15, 1982·The Biochemical Journal·R F Irvine
May 1, 1980·The Journal of Cell Biology·C GajdusekS M Schwartz
Oct 9, 1980·The New England Journal of Medicine·M B Sporn, G J Todaro

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Citations

Oct 1, 1995·The British Journal of Ophthalmology·O NishiE Shirasawa
Jan 1, 1994·Scandinavian Journal of Rheumatology. Supplement·G W Duff
Oct 31, 2015·Neuro-oncology·Edjah K NduomAmy B Heimberger

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