Polypeptides extracted from Eupolyphaga sinensis walker via enzymic digestion alleviate UV radiation-induced skin photoaging

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Nan ZhangYongxing Zhao

Abstract

The traditional medicine-Eupolyphaga sinensis walker is a rich source of functional proteins and peptides. In this study, Eupolyphaga sinensis walker were identified to include fifteen amino acids, of which hydrophobic amino acids accounted for 46.7%. Eupolyphaga sinensis walker polypeptides (EPs) were extracted by sequentially hydrolyzing with pepsin and trypsin. EPs could effectively scavenge 1,1-diphenyl-2-picrylhydrazyl radical (DPPH·), superoxide anion radical (O2-), and hydroxyl radical (OH-), and reduce ferric solution in vitro. EPs also enhanced the activities of Ssuperoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPH-Px), increased the contents of hydroxyproline (HYP), and reduced the content of Malondialdehyde (MDA) in photoaged mice skin. Histological study confirmed that EPs improved UV irradiation-induced damage of skin texture and morphology. Therefore, the extracted EPs are effective antioxidants and can serve as powerful treatment for skin photoaging.

References

Jan 24, 1998·Journal of Photochemistry and Photobiology. B, Biology·D P Steenvoorden, G M van Henegouwen
Mar 1, 2000·Biochemical and Biophysical Research Communications·H Yasui, H Sakurai
Oct 31, 2001·Journal of Photochemistry and Photobiology. B, Biology·M WlaschekK Scharffetter-Kochanek
May 30, 2002·Journal of Agricultural and Food Chemistry·B Matthäus
Mar 17, 2004·Toxicology and Applied Pharmacology·Mohammad AtharDavid R Bickers
Aug 24, 2005·The Journal of Nutritional Biochemistry·Niranjan RajapakseSe-Kwon Kim
Mar 18, 2006·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Th HerrlingJ Fuchs
Jun 23, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·D Venkat RatnamM N V Ravi Kumar
Sep 22, 2006·Bioorganic & Medicinal Chemistry Letters·Zhanyong GuoPengcheng Li
Feb 13, 2008·Photochemistry and Photobiology·Vaqar M AdhamiFarrukh Afaq
Jul 6, 2010·Peptides·Bahareh H Sarmadi, Amin Ismail
Jul 19, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Xue-Xuan FengZhi-Xiu Lin
Sep 23, 2014·Experimental Dermatology·Claire BattieMichèle Verschoore
Nov 15, 2008·Food Chemistry·Zhengjun XieZhengyu Jin

❮ Previous
Next ❯

Citations

Aug 11, 2020·Critical Reviews in Food Science and Nutrition·David Fonseca HernandezLuis Mojica
Jul 1, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Wentao Jia, Lina Wang
Feb 23, 2021·Drug Development and Industrial Pharmacy·Jing LiMinjie Sun

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.