Polypharmacy in a hospitalized psychiatric population: risk estimation and damage quantification

BMC Psychiatry
J Carmona-HuertaR Medina-Dávalos

Abstract

Polypharmacy increases the risk of pharmacological interactions, prevalence of secondary effects and with this the lack of adherence to treatment. It is estimated that between 10 and 40% of patients hospitalized in psychiatric institutions are prescribed more than one antipsychotic. The objective of the present study was to identify the prevalence of polypharmacy, evaluate adverse effects associated to the use of psych drugs and to estimate the risk in specific groups. We carried out a longitudinal, retrospective study that included the analysis of all discharged patients (n = 140) in the first trimester of the year in a psychiatric hospital in Mexico. The information was classified into 7 sections: sociodemographic, diagnosis, clinical follow-up information, prescribed drugs, adverse reactions, substance abuse, laboratory and complementary results. Risk estimation was obtained with Odds Ratios, to correlate continuous variables Pearson's correlation was used. Student's T and Mann Whitney's U were used to compare 2 independent samples; multiple and linear regressions were carried out. The mean number of drugs used during hospitalization was 7.8 drugs per patient. The mean prescribed psych drugs was 4.07. The mean antipsychotic ...Continue Reading

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Citations

Nov 5, 2019·Critical Reviews in Clinical Laboratory Sciences·Cierra N SharpRoland Valdes
Jan 9, 2021·Journal of Neural Transmission·Gudrun HefnerAnsgar Klimke
Jan 14, 2021·Journal of Neural Transmission·Sermin TotoAnsgar Klimke
Apr 18, 2021·Clinical Psychology Review·Amitai AbramovitchAvraham Schweiger
Jun 3, 2021·Journal of Clinical Medicine·Michal OrdakMagdalena Bujalska-Zadrozny

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Software Mentioned

Statistical Package for the social sciences
R Project for Statistical Computing
SPSS “
RStudio ”
R

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