Polypharmacy in elderly patients

The American Journal of Geriatric Pharmacotherapy
Emily R HajjarJoseph T Hanlon

Abstract

Polypharmacy (ie, the use of multiple medications and/or the administration of more medications than are clinically indicated, representing unnecessary drug use) is common among the elderly. The goal of this research was to provide a description of observational studies examining the epidemiology of polypharmacy and to review randomized controlled studies that have been published in the past 2 decades designed to reduce polypharmacy in older adults. Materials for this review were gathered from a search of the MEDLINE database (1986-June 2007) and International Pharmaceutical Abstracts (1986-June 2007) to identify articles in people aged >65 years. We used a combination of the following search terms: polypharmacy, multiple medications, polymedicine, elderly, geriatric, and aged. A manual search of the reference lists from identified articles and the authors' article files, book chapters, and recent reviews was conducted to identify additional articles. From these, the authors identified those studies that measured polypharmacy. The literature review found that polypharmacy continues to increase and is a known risk factor for important morbidity and mortality. There are few rigorously designed intervention studies that have been ...Continue Reading

References

Aug 1, 1987·Annals of Internal Medicine·E B LarsonB V Reifler
Mar 1, 1988·Journal of the American Geriatrics Society·L Nolan, K O'Malley
Dec 1, 1988·Journal of the American Geriatrics Society·R E GrymonpreP R Montgomery
Feb 1, 1988·Journal of the American Geriatrics Society·L Nolan, K O'Malley
Sep 1, 1982·Journal of the American Geriatrics Society·P S GermanC R Smith
Dec 1, 1994·Journal of the American Geriatrics Society·K SchmaderJ R Feussner
Jun 1, 1994·Drugs & Aging·R B Stewart, J W Cooper
Jun 22, 1999·International Journal of Nursing Studies·A A Ryan
Aug 24, 1999·European Journal of Clinical Pharmacology·H F ThomasD K Luscombe
Jan 16, 2002·JAMA : the Journal of the American Medical Association·David W KaufmanAllen A Mitchell
Oct 18, 2002·Journal of Clinical Epidemiology·Tarja LinjakumpuRaimo Isoaho
Mar 8, 2003·JAMA : the Journal of the American Medical Association·Jerry H GurwitzDavid W Bates
Jan 27, 2004·The Annals of Pharmacotherapy·Joseph T HanlonKenneth E Schmader
Jan 30, 2004·British Journal of Clinical Pharmacology·J K Aronson
Mar 10, 2004·The American Journal of Medicine·Kenneth E SchmaderHarvey Jay Cohen
Sep 29, 2004·Journal of the American Geriatrics Society·Joseph V AgostiniMary E Tinetti
Mar 17, 2005·JAMA : the Journal of the American Medical Association·Daniela FialováUNKNOWN AdHOC Project Research Group
Sep 3, 2005·Journal of the American Geriatrics Society·Emily R HajjarKenneth E Schmader
Sep 24, 2005·Journal of Aging and Health·Christine M RubyRichard C Bump
Oct 20, 2005·Pharmacotherapy·Barbara J ZarowitzEdward L Peterson
Nov 1, 2005·The American Journal of Geriatric Pharmacotherapy·Mary T Roth, Jena L Ivey
Mar 3, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·David V EspinoKyriakos Markides
May 25, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Joseph T HanlonKenneth E Schmader
May 30, 2006·The American Journal of Geriatric Pharmacotherapy·Julia K NguyenEunice Lo
Jul 25, 2006·The American Journal of Geriatric Pharmacotherapy·Katrina T CannonMiguel A Zuniga
Oct 14, 2006·Journal of the American Geriatrics Society·Michael A SteinmanPeter J Kaboli

❮ Previous
Next ❯

Citations

Nov 19, 2013·International Journal of Clinical Pharmacy·Emily Reeve, Michael D Wiese
Mar 24, 2012·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·J FuchsC Scheidt-Nave
Sep 12, 2012·European Journal of Clinical Pharmacology·Ruth E HubbardKenneth W Woodhouse
Jun 17, 2011·Zeitschrift für Gerontologie und Geriatrie·A BahrmannP Oster
Nov 28, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Ting Ting YeohLita Chew
Mar 29, 2011·International Journal of Clinical Pharmacy·Melanie Isabelle Brulhart, Joel Pierre Wermeille
Apr 25, 2012·International Journal of Clinical Pharmacy·Elisabete Pinto BorgesAna Filipa Macedo
Dec 7, 2013·International Journal of Clinical Pharmacy·Juha SinnemäkiMarja Airaksinen
Apr 23, 2013·Journal of General Internal Medicine·Carol HoltzmanUNKNOWN , and the HOPS Investigators
Jun 12, 2012·Current Psychiatry Reports·Regina Bussing, Almut G Winterstein
Dec 4, 2012·Dermatology and Therapy·Bruce E StroberMelodie Young
May 21, 2013·Accident; Analysis and Prevention·Joel Monárrez-EspinoLucie Laflamme
Apr 10, 2003·The Psychiatric Clinics of North America·Peter F BuckleyJames L Knoll
May 13, 2011·Aging & Mental Health·Chi-pun Ben LiuIris Chi
Nov 20, 2012·Journal of Nutrition in Gerontology and Geriatrics·Roschelle Heuberger
Jan 6, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Graziano OnderUNKNOWN SHELTER Project
Jan 3, 2012·The Journal of Cardiovascular Nursing·Nancy M AlbertMargaret Murray
Oct 11, 2012·Medical Care·Walid F GelladJoseph T Hanlon
Dec 3, 2010·BMC Clinical Pharmacology·Bo HovstadiusGöran Petersson
May 29, 2009·BMC Clinical Pharmacology·Bo HovstadiusGöran Petersson
Apr 27, 2010·The Oncologist·Ronald J MaggioreArti Hurria
Jun 16, 2012·American Journal of Public Health·Carl J CaspersenAnn L Albright
Jul 3, 2013·Clinical Interventions in Aging·Lauren J GleasonKrupa Shah
Dec 19, 2013·Clinical Interventions in Aging·Yichayaou BelooseskyAvraham Weiss
Jun 10, 2010·Vascular Health and Risk Management·Rainer Düsing
Nov 26, 2009·Drugs & Aging·Johanna JyrkkäSirpa Hartikainen
Dec 10, 2009·Clinical Drug Investigation·J Simon BellKaisu H Pitkälä
May 11, 2010·Drugs & Aging·Howard Smith, Patricia Bruckenthal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the American Geriatrics Society
Michael A SteinmanPeter J Kaboli
The American Journal of Geriatric Pharmacotherapy
Lisa L DwyerElizabeth A Rechtsteiner
JAMA : the Journal of the American Medical Association
David W KaufmanAllen A Mitchell
© 2021 Meta ULC. All rights reserved