Polypharmacy in multimorbid older adults: protocol for a systematic review

Systematic Reviews
Caroline SiroisValérie Émond

Abstract

Polypharmacy, the concurrent use of multiple medications, consistently evokes a negative connotation, notably because it is associated with a plethora of adverse events. Nonetheless, the number of individuals exposed to polypharmacy is increasing steeply, especially for older people with multiple diseases. There is a need to carefully study the phenomenon at the population scale to full assess the associated health outcomes. Yet, this reveals a complex task because there exists no consensus indicator of polypharmacy. In fact, the definitions of polypharmacy are heterogeneous and its predisposing factors and associated outcomes are not well defined. The goal of this systematic review is to summarize the literature on polypharmacy in multimorbid individuals aged 65 years and over, targeting three objectives: (1) to identify the definitions of polypharmacy that are used in the context of multimorbidity among older individuals (≥65 years); (2) to ascertain predisposing and concurrent factors associated with polypharmacy; and (3) to describe positive and negative outcomes of polypharmacy among older individuals, including hospitalizations, mortality and costs. We will include publications from 2004 to 2016 that target four concepts:...Continue Reading

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Citations

Sep 1, 2019·Pharmacy : Journal of Pharmacy, Education and Practice·Caroline SiroisValérie Émond
Jul 3, 2021·Pharmacoepidemiology and Drug Safety·Johan Van der HeydenOlivier Bruyère

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