Polypharmacy in older people: lessons from 10 years of experience with the REPOSI register

Internal and Emergency Medicine
P M MannucciREPOSI Collaborators (REPOSI is the acronym of REgistro POliterapie SIMI, Società Italiana di Medicina Interna)

Abstract

As a consequence of population aging, we have witnessed in internal medicine hospital wards a progressive shift from a population of in-patients relatively young and mainly affected by a single ailment to one of ever older and more and more complex patients with multiple chronic diseases, followed as out-patients by many different specialists with poor integration and inevitably treated with multiple medications. Polypharmacy (defined as the chronic intake of five or more drugs) is associated with increased risks of drug-drug interactions and related adverse effects, prescription and intake errors, poor compliance, re-hospitalization and mortality. With this background, the Italian Society of Internal Medicine chose to start in 2008 a prospective register called REPOSI (REgistro POliterapie SIMI, Società Italiana di Medicina Interna) in internal medicine and geriatric hospital wards. The country wide register is an ongoing observatory on multimorbidity and polypharmacy in the oldest old, with the goal to improve prescription appropriateness and, thus to avoid potentially inappropriate medications. The main findings of the register, that has accrued so far, 7005 older patients throughout a 10 year period, are summarized herewith...Continue Reading

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Citations

Oct 28, 2018·Clinical Drug Investigation·Antonino CatalanoAntonino Lasco
Oct 28, 2019·Internal and Emergency Medicine·Salvatore CorraoUNKNOWN RePoSI Investigators
Jul 12, 2020·Internal and Emergency Medicine·Giacomo MarchiDomenico Girelli
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Jan 28, 2021·Journal of Epidemiology and Community Health·Carlotta FranchiAlessandro Nobili
Jun 3, 2021·The American Journal of Gastroenterology·Luca RinaldiAntonio Izzi
Sep 30, 2021·Internal and Emergency Medicine·Maddalena Alessandra WuAntonio Brucato
Sep 20, 2020·Journal of the American Medical Directors Association·Federica ContiPaolo Dionigi Rossi

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