Polyphenol (-)-epigallocatechin gallate protection from ischemia/reperfusion-induced renal injury in normotensive and hypertensive rats

Transplantation Proceedings
Y H JangH R Park

Abstract

The effect of epigallocatechin gallate (EGCG) in an in vivo renal model of ischemia with reperfusion (I/R) was compared between normotensive (WKR) and hypertensive (SHR) rats. WKR (groups I, II, III) and SHR groups (groups IV, V, VI) were divided into three types. Groups I and IV were sham-operated animals; groups II and V were subjected to 45 minutes of renal I/R; and groups III and VI received 10 mg/kg EGCG intravenously at the time of reperfusion. Three days after renal I/R, we compared renal function markers, malondialdehyde (MDA), and histologic changes. Following renal I/R, levels of blood urea nitrogen (BUN) and serum creatinine (sCr) were increased and serum creatinine clearance (CrCl) decreased in group V compared to group II (P < .001). Those receiving EGCG treatment (groups III and VI) had decreased BUN and sCr compared to non-EGCG I/R groups (P < .001), but not surprisingly, higher than sham groups. CrCl was lowest in the SHR groups. The MDA was significantly decreased after EGCG treatment (P = .028 in group III, P = .002 in group VI). Following renal I/R, tissue necrosis was more severe among SHR (P < .001). However, the ratio of regeneration to damage significantly increased in SHR after EGCG treatment. The reperf...Continue Reading

References

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Citations

Oct 26, 2013·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Guan-Hu BaoJonathan Barasch
Mar 7, 2008·Antioxidants & Redox Signaling·Christian DellesAnna F Dominiczak
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Oct 18, 2019·Yeungnam University Journal of Medicine·Jeong Hun SeongKyubok Jin

Related Concepts

Epigallocatechin gallate
Blood Urea Nitrogen Measurement
Zyma
Krebiozen
Bioflavonoids
Hypertensive Disease
Phenols
Rats, Inbred SHR
Renal Blood Flow
Reperfusion Injury

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