Polyphenol-based nutraceuticals for the prevention and treatment of cardiovascular disease: Review of human evidence

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Joao Tomé-Carneiro, Francesco Visioli

Abstract

In addition to prescription drugs, nutraceuticals/functional foods/medical foods are being increasingly added as adjunct treatment of cardiovascular disease (CVD), even though most of them have been exclusively studied in vitro. We review the available evidence (focusing on when the amount of polyphenols' intake was measured) coming from randomized controlled trials (RCTs) of (poly)phenol-based supplements. We conclude that (poly)phenol-based nutraceuticals and functional foods might be indeed used as adjunct therapy of CVD, but additional long-term RCTs with adequate numerosity and with clinically relevant end points are needed to provide unequivocal evidence of their clinical usefulness.

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Citations

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