Polyphenol-Poloxamer Self-Assembled Supramolecular Nanoparticles for Tumor NIRF/PET Imaging

Advanced Healthcare Materials
Xinyu WangMin Yang

Abstract

Self-assembled supramolecular nanoparticles have remarkable benefits in bioimaging and drug delivery. Here it is first reported that polyphenol and poloxamer self-assemble supramolecular nanoparticles (PPNPs). PPNPs are fabricated by multivalent hydrogen bonding between tannic acid and Pluronic F-127 together with hydrophobic interactions of poly(propylene oxide) chains, to be applied in tumor near-infrared fluorescence (NIRF) imaging and positron emission tomography (PET) imaging. With near-infrared fluorescent dyes such as IR780 encapsulated via hydrophobic interactions, PPNPs are used in NIRF imaging. PPNPs with excess phenolic hydroxyl groups chelating positron emitting radionuclide 89 Zr function as a PET contrast agent. The in vivo results show surprisingly higher fluorescence intensity in tumors than in other tissues. In addition, PPNPs exhibit good biocompatibility in various cell lines and do not induce hemolysis in vitro. In this study, it is demonstrated that biodegradable and biocompatible PPNPs are an excellent bimodal contrast agent for in vivo tumor imaging.

References

Sep 22, 2000·Trends in Biotechnology·S M Moghimi, A C Hunter
Aug 15, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Alexander V KabanovValery Yu Alakhov
Jan 7, 2003·Nature Medicine·Ralph Weissleder, Vasilis Ntziachristos
Apr 29, 2004·The American Journal of Clinical Nutrition·Claudine ManachLiliana Jiménez
Nov 24, 2007·Journal of the American Chemical Society·Edouard ObertFrançois Boué
Nov 24, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mar QuiñonesAmaya Aleixandre
Mar 13, 2013·Accounts of Chemical Research·Helen T Chifotides, Kim R Dunbar
Sep 11, 2013·Proceedings of the National Academy of Sciences of the United States of America·Xuzhou YanPeter J Stang
Feb 26, 2014·Nutrients·Nasiruddin KhanCristina Andres-Lacueva
Mar 13, 2014·Angewandte Chemie·Carmen StoffelenJurriaan Huskens
Mar 31, 2015·Nature Nanotechnology·Elizabeth HuynhGang Zheng
Dec 19, 2015·Nature Materials·Matthew J WebberRobert Langer
Jan 21, 2017·Journal of the American Chemical Society·Qianli ZouXuehai Yan
Apr 11, 2016·ACS Biomaterials Science & Engineering·Mikyung ShinHaeshin Lee

❮ Previous
Next ❯

Citations

Sep 18, 2018·Angewandte Chemie·Md Arifur RahimFrank Caruso
Nov 26, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Fuli ZhaoJianhua Zhang
Jan 30, 2020·Advanced Healthcare Materials·Miguel M LeitãoIlídio J Correia
Dec 28, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jie ShengMin Yang
Jun 27, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Madeline T OlsonAaron M Mohs
Sep 3, 2020·Nanomaterials·Sarkar Siddique, James C L Chow
Feb 18, 2021·Chemical Society Reviews·Di WuJesse V Jokerst
Feb 27, 2021·ACS Applied Materials & Interfaces·Salvio Suárez-GarcíaFernando Novio
Apr 30, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Long Wang, Chengcheng Niu
Apr 30, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhenhu GuoLingyun Zhao
Nov 11, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·Menglin WuXuening Zhang
Jun 20, 2021·Advanced Science·Jiating XuYujie Fu
Jun 19, 2021·International Journal of Nanomedicine·Taiki MiyazawaTeruo Miyazawa
Oct 22, 2019·Molecular Pharmaceutics·Cátia DominguesAna Figueiras
Jan 15, 2020·ACS Applied Materials & Interfaces·Jianghua LiMary B Chan-Park
Nov 2, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Ruofei LuWujun Geng
Jan 8, 2022·Bioconjugate Chemistry·Julen AriztiaBertrand Kuhnast

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.