Polyphenol-rich grape powder extract (GPE) attenuates inflammation in human macrophages and in human adipocytes exposed to macrophage-conditioned media

International Journal of Obesity : Journal of the International Association for the Study of Obesity
Angel OvermanMichael K McIntosh

Abstract

Obesity-associated inflammation is characterized by an increased abundance of macrophages (MPhis) in white adipose tissue (WAT), leading to the production of inflammatory cytokines, chemokines and prostaglandins (PGs) that can cause insulin resistance. Grape powder extract (GPE) is rich in phenolic phytochemicals that possess anti-oxidant and anti-inflammatory properties. We examined the ability of GPE to prevent lipopolysaccharide (LPS)-mediated inflammation in human MPhis and silence the cross-talk between human MPhis and adipocytes. We investigated the effect of GPE pretreatment on LPS-mediated activation of mitogen activated protein kinases (MAPKs), nuclear factor kappa B (NF-kappaB) and activator protein-1 (AP-1), and induction of inflammatory genes in human MPhis (that is, differentiated U937 cells). In addition, we determined the effect of GPE pretreatment of MPhis on inflammation and insulin resistance in primary human adipocytes incubated with LPS-challenged MPhi-conditioned medium (MPhi-CM). Pretreatment of MPhis with GPE attenuated LPS-induction of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and IL-1beta; chemokines, such as IL-8 and interferon-gamma inducible protein...Continue Reading

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Citations

Jan 13, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A OvermanM McIntosh
May 27, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Matthew KuennenPope Moseley
May 10, 2011·Annual Review of Nutrition·Chia-Chi Chuang, Michael K McIntosh
Mar 9, 2012·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·M Dall'AstaD Del Rio
Oct 20, 2012·Journal of the Science of Food and Agriculture·Noemi BoquéJ Alfredo Martínez
Jul 17, 2015·Oxidative Medicine and Cellular Longevity·Mika ReinisaloReijo O Karjalainen
Feb 22, 2012·Nutrition·Salvatore Chirumbolo
Oct 1, 2016·International Journal of Molecular Sciences·Juan ZhanGang Xu
Apr 5, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ramgopal Mopuri, Md Shahidul Islam
Jun 29, 2017·Nutrients·Pablo Hernández-AlonsoJordi Salas-Salvadó
Apr 10, 2018·Journal of the American College of Nutrition·Sedigheh AsgaryMahtab Keshvari
Jan 10, 2017·Frontiers in Pharmacology·Wei-Chun ChenJin-Ching Lee
Mar 7, 2021·Nutrients·Hira ShakoorLily Stojanovska
Dec 6, 2012·Journal of Agricultural and Food Chemistry·Chia-Chi ChuangMichael K McIntosh

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