Polyphenolic Compounds, Antioxidant, and Cardioprotective Effects of Pomace Extracts from Fetească Neagră Cultivar

Oxidative Medicine and Cellular Longevity
Ştefania Silvia BaleaMarcel Pârvu

Abstract

Grape pomace is a potential source of natural antioxidant agents. Phenolic compounds and antioxidant and cardioprotective properties of fresh and fermented pomace extracts obtained from Vitis vinifera L. red variety Fetească neagră grown in Romania in 2015 were investigated. Grape pomace extracts total phenolic index, total tannins, total anthocyanins, proanthocyanidins, flavan-3-ol monomers, stilbenes, and DPPH free radical scavenger were measured. The effect of a seven-day pretreatment with grape pomace extracts on the isoprenaline-induced infarct-like lesion in rats was assessed by ECG monitoring, serum levels of creatine kinase, aspartate transaminase, and alanine transaminase. Total serum oxidative status, total antioxidant response, oxidative stress index, malondialdehyde, total thiols, and nitric oxide have been also assessed. Higher phenolic content and antioxidant activity were found in fermented pomace extracts when compared to fresh pomace extracts. Pretreatment with grape pomace extracts significantly improved cardiac and oxidative stress parameters. In conclusion, Fetească neagră pomace extracts had a good in vitro antioxidant activity due to an important phenolic content. In vivo, the extracts had cardioprotective...Continue Reading

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Citations

Aug 4, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Paul-Mihai BoarescuSorana D Bolboacă
Nov 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marcel PârvuAdrian B Ţigu
Dec 11, 2019·Pharmaceutics·Maria Adriana NeagAnca Dana Buzoianu
Aug 27, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ana-Maria BrezoiuDaniela Berger
Feb 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michał OtrębaAnna Rzepecka-Stojko
Nov 20, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michał OtrębaAnna Rzepecka-Stojko
Mar 3, 2021·Food Research International·Óscar A Muñoz-BernalEmilio Alvarez-Parrilla
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ioana Corina BocsanAnca Dana Buzoianu

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Methods Mentioned

BETA
MDS
RSA
MDA

Software Mentioned

Analyst MDS
SPSS

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