Polyphenolic compounds for treating neurodegenerative disorders involving protein misfolding

Expert Review of Proteomics
Lap Ho, G Pasinetti

Abstract

A diverse group of neurodegenerative diseases are characterized by progressive, age-dependent intracellular formation of misfolded protein aggregates. These include Alzheimer's disease, Huntington's disease, Parkinson's disease and a number of tau-mediated disorders. There is no effective treatment for any of these disorders; currently approved interventions are designed to treat disease symptoms and generally lead to modest modulation of clinical symptoms. None are known to mitigate underlying neuropathologic mechanisms and, thus, it is not unexpected that existing treatments appear ineffective in modulating disease progression. We note that these neurodegenerative disorders all share a common mechanistic theme in that depositions of misfolded protein in the brain is a key molecular feature underlying disease onset and/or progression. While previous studies have identified a number of drugs and nutraceuticals capable of interfering with the formation and/or stability of misfolded protein aggregates, none have been demonstrated to be effective in vivo for treating any of the neurodegenerative disorders. We hereby review accumulating evidence that a select nutraceutical grape-seed polyphenolic extract (GSPE) is effective in vitr...Continue Reading

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Citations

Feb 1, 2013·The New England Journal of Medicine·Monte S Willis, Cam Patterson
Oct 26, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lap HoGiulio Maria Pasinetti
Jun 20, 2014·Proteomics. Clinical Applications·Federica Del Monte, Giulio Agnetti
Aug 10, 2011·Biochemistry Research International·Toshihiko TodaTakahiko Shimizu
Sep 1, 2015·ACS Chemical Neuroscience·Ravit MalishevRaz Jelinek
Oct 16, 2014·Biochimica Et Biophysica Acta·Giulio Maria PasinettiLauren Dubner
Jan 21, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Parvana Hajieva
Apr 18, 2018·Journal of Alzheimer's Disease : JAD·Giulio Maria PasinettiLap Ho
Apr 4, 2019·Frontiers in Pharmacology·Hayate JavedShreesh Kumar Ojha

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