Polyphenolic extract attenuates fatty acid-induced steatosis and oxidative stress in hepatic and endothelial cells

European Journal of Nutrition
Laura VerganiPatrizia Perego

Abstract

Phenolic compounds (PC) of virgin olive oil exert several biochemical and pharmacological beneficial effects. Some dietary PC seem to prevent/improve obesity and metabolic-related disorders such as non-alcoholic fatty liver disease (NAFLD). We investigated the possible effects of PC extracted from olive pomace (PEOP) and of the main single molecules present in the extract (tyrosol, apigenin, oleuropein, p-coumaric and caffeic acid) in protecting hepatocytes and endothelial cells against triglyceride accumulation and oxidative stress. Rat hepatoma and human endothelial cells were exposed to a mixture of oleate/palmitate to mimic the condition of NAFLD and atherosclerosis, respectively. Then, cells were incubated for 24 h in the absence or in the presence of PC or PEOP. Different parameters were evaluated, such as lipid accumulation and oxidative stress-related markers. In hepatic cells, expression of peroxisome proliferator-activated receptors (PPARs) and of stearoyl-CoA desaturase 1 (SCD-1) were assessed as index of lipid metabolism. In endothelial cells, expression of intercellular adhesion molecule-1 (ICAM-1), activation of nuclear factor kappa-B (NF-kB), release of nitric oxide (NO), and wound-healing rate were assessed as i...Continue Reading

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Citations

Jan 5, 2018·Natural Product Research·Monica AvernaEdon Melloni
Jan 24, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ilaria DemoriElena Grasselli
Sep 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Laura VerganiNiccolò Miraglia
Dec 10, 2019·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Francesca BaldiniGiuseppe Calamita
Jan 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chiara LambruschiniLisa Moni
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zeinab El RashedIlaria Demori
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zeinab El RashedIlaria Demori

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