PMID: 22583399May 16, 2012Paper

Polyphenols counteract tumor cell chemoresistance conferred by multidrug resistance proteins

Anti-cancer Agents in Medicinal Chemistry
Krystyna Michalak, Olga Wesolowska

Abstract

One of the main reasons of cancer resistance to chemotherapeutic treatment is the presence of different ABC multidrug transporters in plasma membranes. The transporters extrude wide spectrum of anticancer agents out of cancer cells at the expense of energy derived from ATP-hydrolysis. Plant-origin polyphenolic compounds, mainly flavonoids and stilbenes or their synthetic derivatives, can modulate the main ABC transporters responsible for cancer drug resistance, including P-glycoprotein, MRP1 and BCRP. The recent studies on different resistant cancer cell lines enabled the discovery of a number of polyphenolic compounds able to reverse drug resistance in vitro and these compounds could be promising candidates for further clinical trials. The review summarizes the recent advances in the field of polyphenols interaction with ATP-binding cassette multidrug transporters. The mechanism of flavonoids interactions with the multidrug transporters and the structure-activity relationship are also discussed.

Citations

Oct 8, 2015·Drug Metabolism and Personalized Therapy·Verónica MiguelAna I Álvarez
Feb 17, 2015·Journal of Advanced Research·Hossam M AbdallahAli M El-Halawany
Dec 3, 2014·Cell Biochemistry and Biophysics·Jianjun DingQianxue Chen
Jul 28, 2016·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Wen LiZhe-Sheng Chen
Nov 9, 2016·Molecular Cancer·Abhijeet DeshmukhArun Dharmarajan
Jan 26, 2017·Frontiers in Pharmacology·Raafat El-AwadyGhada Elakraa
Jul 29, 2017·Phytotherapy Research : PTR·Marcello IritiRobert D Wojtyczka
Feb 2, 2018·Oxidative Medicine and Cellular Longevity·Tomasz KubrakJanusz Kocki
Jun 8, 2018·Current Medicinal Chemistry·Tijana StankovićMilica Pešić
Dec 10, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Sina DarziEhsan Aali
May 7, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Trina H GarcíaLuca Rastrelli
Feb 18, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Imran Shair MohammadLifang Yin

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