Polyphenols enhance the activity of alkylating agents in leukaemia cell lines

Oncotarget
A A MahbubN Jordan-Mahy

Abstract

Polyphenols have been shown to sensitize solid tumours to alkylating agents such as cisplatin, and induce apoptosis and/or cell-cycle arrest. Here, we assess the effects of five polyphenols alone and in combination with three alkylating agents: cisplatin, cyclophosphamide and chlorambucil in lymphoid and myeloid leukaemia cells lines, and non-tumour control cells. In lymphoid leukaemia cell lines there was a synergistic reduction in ATP and glutathione levels, an induction of cell cycle arrest, DNA damage and apoptosis when quercetin, apigenin, emodin and rhein were combined with cisplatin and cyclophosphamide; and when apigenin and rhein were combined with chlorambucil. In myeloid leukaemia cells quercetin, apigenin and emodin showed a similar synergistic effect with all alkylating agents; however antagonistic effects were observed with some or all alkylating agents when combined with emodin, rhein and cis-stilbene. All synergistic effects were associated with reduced glutathione levels, DNA damage and apoptosis; whilst during antagonism the reverse effects were observed. The combination of alkylating agents, particularly cisplatin with polyphenols could be promising for the treatment of lymphoid leukaemias, with apigenin show...Continue Reading

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Citations

Apr 4, 2021·International Journal of Molecular Sciences·Hamza A AlaswadNicola Jordan-Mahy
Sep 28, 2021·Computational and Structural Biotechnology Journal·Yifei WuZhong-Ru Xie
Oct 31, 2021·Cancer Cell International·Zahra NozhatAmirhossein Ahmadi

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Methods Mentioned

BETA
fluorescence microscopy

Software Mentioned

Stats Direct
Nucview
Cell
Stats
FlowJo

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Apoptosis

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