Polyphenols in chocolate, which have antioxidant activity, modulate immune functions in humans in vitro

Cellular Immunology
C SanbongiT Sakane

Abstract

We studied the effects of antioxidants from chocolate, cacao liquor polyphenol (CLP), on human immune functions in vitro. CLP is an enriched polyphenol fraction purified from cacao liquor that is a major component of chocolate. It has been shown that polyphenols have antioxidant activity, and reactive oxygen species (ROS) are involved in immune responses. CLP inhibited both hydrogen peroxide and superoxide anion, typical ROS, production by phorbol myristate acetate-activated granulocytes. CLP also inhibited menadione-induced production of both hydrogen peroxide and superoxide anion in normal human peripheral blood lymphocytes (PBL). CLP treatment of normal PBL in vitro inhibited mitogen-induced proliferation of T cells and polyclonal Ig production by B cells in a dose-dependent manner. CLP treatment inhibited both IL-2 mRNA expression of and IL-2 secretion by T cells. These results suggest that antioxidant CLP has immunoregulatory effects.

References

Mar 27, 1992·Biochemical Pharmacology·E Middleton, C Kandaswami
Jan 1, 1990·Methods in Enzymology·B Halliwell, J M Gutteridge
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·F J StaalL A Herzenberg
Jun 1, 1989·The Biochemical Journal·G E KassS Orrenius
Nov 10, 1995·Archives of Biochemistry and Biophysics·T NishiuchiK Utsumi
Dec 1, 1995·The Journal of Experimental Medicine·P JeanninJ Y Bonnefoy
Oct 22, 1993·Cell·D M HockenberyS J Korsmeyer
Aug 22, 1995·Biochimica Et Biophysica Acta·S D GoldstoneN H Hunt
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·B N AmesT M Hagen
May 28, 1993·Biochemical and Biophysical Research Communications·Y J Suzuki, L Packer
May 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C K Sen, L Packer
Jun 1, 1996·The American Journal of Clinical Nutrition·R A Jacob, B J Burri
Sep 21, 1996·Lancet·A L WaterhouseJ L Donovan
Nov 30, 1996·Lancet·K KondoH Itakura
Feb 1, 1960·The Biochemical Journal·W G FORSYTH, J B ROBERTS

❮ Previous
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Citations

Oct 2, 2008·Journal of Thrombosis and Thrombolysis·Giuseppe LippiGiovanni Targher
Jan 9, 2008·The British Journal of Nutrition·Jean-François BissonMichaël Messaoudi
Jan 8, 2009·The British Journal of Nutrition·Emma Ramiro-Puig, Margarida Castell
Jul 19, 2005·The British Journal of Nutrition·Emma RamiroMargarida Castell
Dec 19, 1998·BMJ : British Medical Journal·I M Lee, R S Paffenbarger
Jan 5, 2006·Nutrition & Metabolism·Eric L DingSaket Girotra
Feb 24, 2001·Drug Metabolism and Drug Interactions·H MoiniL Packer
Jul 3, 2013·Nutrients·Alejandro CuevasDulcineia S P Abdalla
Oct 12, 2000·Biochemical and Biophysical Research Communications·S B LotitoC G Fraga
Jun 29, 2000·Biochemical and Biophysical Research Communications·J P SpencerC Rice-Evans
Dec 3, 2013·Current Pain and Headache Reports·Mina G NashedGurmit Singh
Jan 10, 2014·Talanta·Rinat Levi YanusZeev Karpas
Nov 15, 2012·Oxidative Medicine and Cellular Longevity·I AndújarJ L Ríos
Oct 3, 2014·Journal of Industrial Microbiology & Biotechnology·Jingyuan LiWeidong Huang
Apr 1, 2006·Nutrition Reviews·Mary B Engler, Marguerite M Engler
Dec 21, 2000·Current Atherosclerosis Reports·A L Catapano, E Tragni
Apr 1, 2015·International Journal of Molecular Sciences·Bo ZhangFei He
Dec 10, 1999·Renal Failure·E N Wardle
Dec 8, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Soumaya Kilani-JaziriLeila Ghedira-Chekir
Mar 18, 2016·The British Journal of Nutrition·Christopher T FordMalcolm J Jackson
Jul 23, 2014·Asian-Australasian Journal of Animal Sciences·J C ParkS K Park
Jun 11, 2014·Critical Reviews in Food Science and Nutrition·Ilaria PelusoMauro Serafini
Apr 14, 2017·Nature Reviews. Rheumatology·Shani DahanYehuda Shoenfeld
Mar 8, 2017·Foods·Cédric De TaeyeSonia Collin
Nov 25, 2014·Molecular Nutrition & Food Research·Estanislau NavarroHelmut Schröder
Jan 15, 2003·Journal of Mass Spectrometry : JMS·Ferran Sánchez-RabanedaRosa M Lamuela-Raventós
Nov 22, 2013·Molecular Nutrition & Food Research·Faisal AliSander Kersten
Mar 18, 2009·Circulation·Roberto CortiThomas F Lüscher
Dec 2, 1999·FEBS Letters·G E Arteel, H Sies
Dec 20, 2007·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Jean-François BissonMichaël Messaoudi
Jun 24, 2006·Journal of Cardiovascular Pharmacology·Carlo SelmiM Eric Gershwin
Mar 26, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jae B Park
Apr 17, 2008·Cardiology in Review·Ramona Mehrinfar, William H Frishman
Oct 18, 2008·Molecular Nutrition & Food Research·Teresa Pérez-BerezoMargarida Castell

❮ Previous
Next ❯

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