[Polyphenon E. A new topical therapy for condylomata acuminata].

Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
G Gross

Abstract

Treatment of genital warts (condylomata acuminata) is still not completely satisfactory, despite the introduction of imiquimod 5% cream. With the development of Polyphenon E 15% ointment, progress has been made towards optimized, patient-friendly treatment of genital warts. Polyphenon E is a mixture of different polyphenols/catechins from green tea extracts (Camilla sinensis), which are known to have antioxidative, antiinflammatory, anti-proliferative and anticancer activities. In 3 placebo-controlled clinical studies safety and efficacy of Polyphenol E 15% ointment was studied in a total of 1400 patients with genital warts from Europe, North- and South America as well as South Africa. Complete responses with total healing of genital warts were seen in 54.9% of the patients in contrast to 35.4% of patients receiving placebo (p >0.001) (Combined study data). The recurrence rate was 6.2%. Polyphenon E offers special advantages with regard to its very good safety profile. Systemic adverse reactions are unlikely. Mild to moderate local reactions are of short duration. "Drug-holidays" are not necessary and the ointment does not have to be washed off. There is no contraindication for uncircumcised men with genital warts.

References

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Apr 16, 1998·Genitourinary Medicine·I Simms, C K Fairley
Jul 2, 1999·International Journal of Antimicrobial Agents·G Gross
Jun 13, 2001·BMC Infectious Diseases·R A MooreD Hicks
May 27, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ralph P InsingaEvan R Myers
Mar 9, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Charles J N Lacey
May 15, 2007·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·G Gross
Aug 21, 2007·JAMA : the Journal of the American Medical Association·Allan HildesheimUNKNOWN Costa Rican HPV Vaccine Trial Group
Nov 17, 2007·The Journal of Infectious Diseases·Susanne Krüger KjaerMari Nygård
May 21, 2010·Deutsche medizinische Wochenschrift·G GrossUNKNOWN für das HPV-Management Forum

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Citations

Jan 6, 2011·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·G Gross
Jun 23, 2009·Sexually Transmitted Diseases·Aris D'AmbrogioJean-Claude Givel

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