Polyphosphate, an active molecule derived from probiotic Lactobacillus brevis, improves the fibrosis in murine colitis

Translational Research : the Journal of Laboratory and Clinical Medicine
Shin KashimaYutaka Kohgo

Abstract

Inflammatory bowel disease frequently causes intestinal obstruction because of extensive fibrosis. This study investigated whether polyphosphate (poly P), an active molecule derived from Lactobacillus brevis, could improve the fibrosis in a model of chronic colitis. In this study, dextran sodium sulfate (DSS)-induced chronic colitis models and trinitrobenzene sulfonic acid (TNBS)-induced colitis models were used as models of fibrosis. To clarify the mechanism responsible for the observed effects, Caco-2/brush border epithelial (BBE) and naive T helper lymphocyte (THP)-1 cells were treated with lipopolysaccharide (LPS) to induce inflammation. Non-cancer human colon fibroblast (CCD-18) cells were treated with transforming growth factor beta 1 (TGF-β1) to induce fibrosis. The expression levels of fibrosis- and inflammation-associated molecules were evaluated by both a Western blotting analysis and reverse transcriptase-polymerase chain reaction (RT-PCR). The histologic inflammation and fibrosis were significantly improved in the group administered poly P in both the DSS and TNBS colitis models. The levels of interleukin 1β (IL-1β) and tumor necrosis factor α (TNF-α) were significantly decreased by poly P treatment. The expression ...Continue Reading

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Citations

Oct 16, 2015·Biochemical and Biophysical Research Communications·Kazuyuki TanakaYutaka Kohgo
Nov 12, 2016·Journal of Animal Science and Biotechnology·Jean-Paul Lallès
Apr 14, 2017·Current Opinion in Gastroenterology·Giovanni Latella, Florian Rieder
Mar 17, 2016·Critical Reviews in Food Science and Nutrition·Qinglong Wu, Nagendra P Shah
Jun 24, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Masami IjiriToshikatsu Okumura
Aug 11, 2016·Nature Communications·Hiroaki KonishiYutaka Kohgo
Sep 13, 2019·Clinical Pharmacology and Therapeutics·Mikihiro FujiyaToshikatsu Okumura
Jul 17, 2020·Frontiers in Plant Science·Emanuel Sanz-LuqueArthur R Grossman
Sep 25, 2018·Frontiers in Microbiology·Cristina AlcántaraVicente Monedero

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