Polypill: for Pollyanna

International Journal of Stroke : Official Journal of the International Stroke Society
J David Spence

Abstract

A single pill containing a statin, thiazide diuretic, beta-blocker, angiotensin receptor antagonist, folate and ASA has been proposed for all people over age 55, with the aim of reducing cardiovascular disease by 80%. Unfortunately, there are insurmountable problems with choosing appropriate constituents of any such single remedy. Adverse effects, drug interactions, inter-individual variation in drug metabolism, and underlying causes of hypertension that differ between patients require individualized therapy. A single pill that will succeed in all patients is not only practically, but conceptually, an inappropriate approach for the prevention of cardiovascular disease.

References

Nov 1, 1977·Clinical Pharmacology and Therapeutics·M G TweeddaleJ Ruedy
Jan 1, 1975·Annals of Internal Medicine·L WallachK G Dawson
Oct 1, 1984·Drugs·T Dyckner, P O Wester
Apr 1, 1997·Clinical Pharmacology and Therapeutics·J D Spence
Jun 11, 1997·JAMA : the Journal of the American Medical Association·I M GrahamG Andria
Jul 24, 1997·The New England Journal of Medicine·O NygårdS E Vollset
May 20, 1998·Clinical Pharmacology and Therapeutics·T KantolaP J Neuvonen
May 13, 1999·The New England Journal of Medicine·P F JacquesI H Rosenberg
Aug 25, 1999·Clinical Pharmacology and Therapeutics·J J LiljaP J Neuvonen
Mar 29, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B J GallayR C Davidson
Jul 10, 2002·Hypertension·Emma H BakerGraham A MacGregor
Nov 2, 2002·Journal of the American Geriatrics Society·Suparna RajanSally P Stabler
Jun 28, 2003·BMJ : British Medical Journal·N J Wald, M R Law
Jul 5, 2003·The Annals of Pharmacotherapy·Aasma ShaukatMaria R Baer
Jan 20, 2004·Advances in Renal Replacement Therapy·Pauline A Swift, Graham A Macgregor
Feb 26, 2004·Neurology·Jens P Dreier, Matthias Endres
Jun 23, 2004·British Journal of Clinical Pharmacology·Jari J LiljaPertti J Neuvonen
Aug 4, 2004·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Emmanuel AndrèsJean-Frédéric Blicklé
Jun 9, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Julie RobertsonJ David Spence
Feb 16, 2006·Journal of Clinical Pharmacy and Therapeutics·R Ismail, L K Teh
Feb 16, 2006·Journal of Epidemiology and Community Health·Oscar H FrancoChris de Laet
Feb 16, 2006·Cerebrovascular Diseases·Pierre Amarenco
Feb 28, 2006·Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace·Massimo F Piepoli
Mar 15, 2006·The New England Journal of Medicine·Eva LonnUNKNOWN Heart Outcomes Prevention Evaluation (HOPE) 2 Investigators
Apr 8, 2006·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·Ulf Landmesser, Helmut Drexler
Apr 11, 2006·European Heart Journal·Peter SleightFaiez Zannad
May 4, 2006·Muscle & Nerve·Georgirene D VladutiuPaul S Phillips
Jun 7, 2006·The Canadian Journal of Cardiology·N A KhanUNKNOWN Canadian Hypertension Education Program
Jul 29, 2006·Stroke; a Journal of Cerebral Circulation·J David Spence
Dec 5, 2006·Current Opinion in Rheumatology·Alan N Baer, Robert L Wortmann
Mar 24, 2007·Nature Clinical Practice. Cardiovascular Medicine·Valentin Fuster, Gines Sanz
Apr 14, 2007·Stroke; a Journal of Cerebral Circulation·Daniel G Hackam, J David Spence
May 12, 2007·The American Journal of Cardiology·Giuseppe CasoWilliam E Lawson
Jun 5, 2007·Pharmacotherapy·Jaekyu Shin, Julie A Johnson
Aug 21, 2007·Lancet Neurology·J David Spence
Aug 19, 2008·International Journal of Stroke : Official Journal of the International Stroke Society·J David Spence

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Citations

Jun 16, 2010·Current Hypertension Reports·Koon K Teo, Yan Liang
Jul 26, 2013·Therapeutic Delivery·Ian G TuckerStephen B Duffull
Sep 24, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shaban A KhaledClive J Roberts
May 20, 2016·Pharmaceutical Research·Mohamed A AlhnanBasel Arafat
Dec 7, 2018·Current Pharmaceutical Design·Musarrat H WarsiSaba Khan
Aug 28, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xiao ZhuLiao Cui

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