Polyploidy in tissue homeostasis and regeneration.

Development
Jan Inge Øvrebø, Bruce A Edgar

Abstract

Polyploid cells, which contain multiple copies of the typically diploid genome, are widespread in plants and animals. Polyploidization can be developmentally programmed or stress induced, and arises from either cell-cell fusion or a process known as endoreplication, in which cells replicate their DNA but either fail to complete cytokinesis or to progress through M phase entirely. Polyploidization offers cells several potential fitness benefits, including the ability to increase cell size and biomass production without disrupting cell and tissue structure, and allowing improved cell longevity through higher tolerance to genomic stress and apoptotic signals. Accordingly, recent studies have uncovered crucial roles for polyploidization in compensatory cell growth during tissue regeneration in the heart, liver, epidermis and intestine. Here, we review current knowledge of the molecular pathways that generate polyploidy and discuss how polyploidization is used in tissue repair and regeneration.

References

Mar 1, 1977·Developmental Biology·J E Sulston, H R Horvitz
Jan 1, 1992·The American Journal of Pediatric Hematology/oncology·T P McDonald
Oct 1, 1966·The Journal of Cell Biology·H P RuschV Gruter
Jan 1, 1994·Journal of Clinical Pathology·S BiesterfeldA Böcking
Jul 5, 1996·Mutation Research·J HeilW Geurtsen
Nov 1, 1996·The American Journal of Physiology·M H SoonpaaL J Field
Jan 1, 1997·The American Journal of Physiology·M H Soonpaa, L J Field
Dec 1, 1996·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·B J ReidD S Levine
Feb 3, 1998·Molecular and Cellular Biology·J S Lanni, T Jacks
Jul 29, 1998·The Plant Journal : for Cell and Molecular Biology·E GendreauJ Traas
Dec 16, 1998·Science·S TanakaJ Rossant
Jan 19, 1999·International Journal of Cardiology·R A PoolmanG Brooks
Apr 25, 2000·Molecular and Cellular Biology·E Santoni-RugiuJ Lukas
Aug 11, 2000·Seminars in Cancer Biology·S Gupta
Nov 14, 2000·Current Opinion in Plant Biology·E KondorosiE Gendreau
Nov 23, 2000·Plant Molecular Biology·J Joubès, C Chevalier
May 12, 2001·Cell·B A Edgar, T L Orr-Weaver
Jan 25, 2002·Journal of Cellular Physiology·Katya RavidMatthew R Jones
Feb 28, 2002·Molecular and Cellular Biology·Ivailo S MihaylovHui Zhang
Nov 1, 1993·The Plant Cell·J. E. MelaragnoA. W. Coleman
Mar 11, 2003·The Journal of Biological Chemistry·Jacques-Emmanuel GuidottiChantal Desdouets
May 27, 2003·Nature Cell Biology·Leslie J SaucedoBruce A Edgar
Sep 23, 2003·Nature Cell Biology·Ryan S UdanGeorg Halder
Nov 13, 2003·Current Opinion in Plant Biology·Keiko Sugimoto-Shirasu, Keith Roberts
Jan 7, 2004·Nature Reviews. Molecular Cell Biology·Zuzana Storchova, David Pellman

❮ Previous
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Citations

May 18, 2019·Cell Cycle·Shuyuan ZhangHao Zhu
Aug 8, 2019·G3 : Genes - Genomes - Genetics·Michael D RotelliBrian R Calvi
Oct 6, 2019·Annual Review of Physiology·Peiheng GanHenry M Sucov
Oct 17, 2019·Cold Spring Harbor Perspectives in Biology·Todd R HeallenJames F Martin
Jul 6, 2019·Médecine sciences : M/S·Romain DonnéChantal Desdouets
Jan 14, 2020·Radiation and Environmental Biophysics·Daria A SkorobagatkoVolodymyr Yu Strashnyuk
Sep 5, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Simon Gemble, Renata Basto
Sep 11, 2020·Bulletin of Experimental Biology and Medicine·L P Sycheva, L M Rozhdestvenskii
Apr 4, 2020·Nature Reviews. Gastroenterology & Hepatology·Romain DonneChantal Desdouets
Apr 13, 2019·Current Genetics·Douglas Maya MilesVincent Géli
Jun 25, 2019·Communications Biology·Kathleen M BroughtonMark A Sussman
Feb 23, 2020·Circulation Research·Wouter Derks, Olaf Bergmann
Aug 26, 2020·JCI Insight·Catherine E LipovskyStacey L Rentschler
Dec 3, 2020·Nature Communications·Marion CremerThomas Cremer
Nov 5, 2020·Circulation Research·Leigh A BradleyMatthew J Wolf
Jan 12, 2020·Communications Biology·Kathleen M BroughtonMark A Sussman
Mar 11, 2021·Developmental Cell·Caroline A DohertyStanislav Y Shvartsman
Apr 9, 2021·Kidney International·Kyung LeeJohn Cijiang He
Jun 3, 2021·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Nora G Peterson, Donald T Fox
Jun 24, 2021·Cell Reports·Ximena ContrerasSimon Hippenmeyer
Jul 13, 2021·Frontiers in Cell and Developmental Biology·Shyama NandakumarLaura Buttitta
Jul 24, 2021·Cerebral Cortex Communications·Thomas JungasAlice Davy
Jul 1, 2021·Cold Spring Harbor Perspectives in Biology·Erin C BaileyVicki P Losick
Oct 7, 2021·The Journal of Cell Biology·Delisa E ClayDonald T Fox
Nov 5, 2021·Nature Metabolism·Sergio Rodriguez-Cuenca, Antonio Vidal-Puig
Nov 16, 2021·Journal of Anatomy·Sonia FantoneManrico Morroni
Apr 12, 2021·Seminars in Cancer Biology·Jing ZhangXinzhe Liu

❮ Previous
Next ❯

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