Polypodium leucotomos extract in atopic dermatitis: a randomized, double-blind, placebo-controlled, multicenter trial

Actas dermo-sifiliográficas
A Ramírez-BoscaGrupo de Anapsos en Dermatitis Atópica y centros de realización del estudio

Abstract

Topical corticosteroids are used to treat inflammation and relieve itching in atopic dermatitis, but their use is limited by adverse reactions. The main aim of this study was to investigate whether daily treatment with Polypodium leucotomos extract would reduce the use of topical corticosteroids in children and adolescents with atopic dermatitis. We also analyzed oral antihistamine use and changes in disease severity. We performed a phase IV randomized, double-blind, placebo-controlled, multicenter trial involving 105 patients aged between 2 and 17 years who were receiving topical corticosteroids to treat moderate atopic dermatitis. The patients were randomized to receive, in addition to their standard treatment, Polypodium leucotomos extract or placebo (both in capsule form) for 6 months. The percentage of days on which topical corticosteroids and other atopic dermatitis treatments were used was calculated. Use of Polypodium leucotomos extract did not significantly reduce the mean (SD) percentage of days on which topical corticosteroids were used (11% [12%] vs 12% [11%] for placebo). A significant reduction was, however, observed for oral histamine use (median percentage of days, 4.5% in the Polypodium leucotomos group and 13....Continue Reading

References

Jan 1, 1993·Dermatology : International Journal for Clinical and Investigative Dermatology
Jan 1, 1997·British Journal of Clinical Pharmacology·J M SempereJ Diaz
Feb 1, 1997·Archives of Disease in Childhood·J C SuT M Nolan
Sep 11, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·J M Sempere-OrtellsJ Pardo
Oct 26, 2002·Dermatology : International Journal for Clinical and Investigative Dermatology·Michael MeurerUNKNOWN CASM-DE-01 study group
Dec 12, 2002·Hospital Medicine·Justin Daniels, John Harper
Apr 16, 2003·The British Journal of Dermatology·C EllisUNKNOWN ICCAD II Faculty
Mar 1, 1964·Archives of Dermatology·A J EDELSTEIN
Jun 5, 2004·Dermatology : International Journal for Clinical and Investigative Dermatology·Michael MeurerUNKNOWN CASM-DE-01 Study Group
May 13, 2006·Experimental Dermatology·Stefanie SchoepeKhusru Asadullah
Apr 4, 2008·The New England Journal of Medicine·Thomas Bieber
Aug 7, 2012·Neurología : publicación oficial de la Sociedad Española de Neurología·J Gállego, M C Gil Alzueta

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Citations

Dec 30, 2014·Archives of Dermatological Research·Olga María Palomino
Mar 28, 2017·Journal of the American Academy of Dermatology·Indermeet KohliIltefat H Hamzavi
Jan 28, 2014·American Journal of Clinical Dermatology·Jonathan I Silverberg
Aug 23, 2016·The British Journal of Dermatology·H NankervisH C Williams
Jul 9, 2016·American Journal of Clinical Dermatology·Brittany L VieiraPeter A Lio
Dec 29, 2020·International Journal of Dermatology·Edward K Hadeler, Andrea D Maderal

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Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

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