Poly(propylene glycol) and urethane dimethacrylates improve conversion of dental composites and reveal complexity of cytocompatibility testing

Dental Materials : Official Publication of the Academy of Dental Materials
Nick J WaltersAnne M Young

Abstract

To determine the effects of various monomers on conversion and cytocompatibility of dental composites and to improve these properties without detrimentally affecting mechanical properties, depth of cure and shrinkage. Composites containing urethane dimethacrylate (UDMA) or bisphenol A glycidyl methacrylate (Bis-GMA) with poly(propylene glycol) dimethacrylate (PPGDMA) or triethylene glycol dimethacrylate (TEGDMA) were characterized using the following techniques: conversion (FTIR at 1 and 4mm depths), depth of cure (BS EN ISO 4049:2009 and FTIR), shrinkage (BS EN ISO 17304:2013 and FTIR), strength and modulus (biaxial flexural test) and water sorption. Cytocompatibility of composites and their liquid phase components was assessed using three assays (resazurin, WST-8 and MTS). UDMA significantly improved conversion, BFS and depth of cure compared to Bis-GMA, without increasing shrinkage. UDMA was cytotoxic at lower concentrations than Bis-GMA, but extracts of Bis-GMA-containing composites were less cytocompatible than of those containing UDMA. PPGDMA improved conversion and depth of cure compared to TEGDMA, without detrimentally affecting shrinkage. TEGDMA was shown by all assays to be highly toxic. Resazurin, but not WST-8 and M...Continue Reading

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Citations

Oct 12, 2016·PloS One·Piyaphong PanpisutAnne Margaret Young
Nov 12, 2016·Journal of Dentistry·Gaute Floer JohnsenHåvard Haugen
Jul 31, 2020·Journal of Functional Biomaterials·Nikos N LygidakisAnne M Young
Nov 13, 2019·Clinical Oral Investigations·Susana BandarraIsabel Barahona
May 31, 2018·Brazilian Oral Research·Daniel SundfeldCarmem Silvia Pfeifer
Apr 21, 2018·Dental Materials : Official Publication of the Academy of Dental Materials·Ruili WangX X Zhu
Nov 30, 2018·Dental Materials : Official Publication of the Academy of Dental Materials·Hongyan ChenMeifang Zhu
Jun 20, 2021·Dental Materials : Official Publication of the Academy of Dental Materials·António H S DelgadoAnne M Young
Jan 20, 2021·ACS Biomaterials Science & Engineering·Alireza AminoroayaSeeram Ramakrishna

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