Polypropylene Sulfide Nanoparticle p24 Vaccine Promotes Dendritic Cell-Mediated Specific Immune Responses against HIV-1

The Journal of Investigative Dermatology
Stephan M CaucheteuxVincent Piguet

Abstract

Delivery of vaccine formulations into the dermis using antigen-coated microneedle patches is a promising and safe approach because of efficient antigen delivery and safety. We evaluated an intradermal vaccine using HIV-1 p24 Gag peptide-conjugated polypropylene sulfide nanoparticles to induce immunity against HIV-1. This peptide-conjugated polypropylene sulfide nanoparticle formulation did not accelerate the maturation of blood- or skin-derived subsets of dendritic cells, either generated in vitro or purified ex vivo, despite efficient uptake in the absence of adjuvant. Moreover, dendritic cell-mediated capture of particulate antigen in this form induced potent HIV-1-specific CD4(+) T-cell responses, as well as B-cell-mediated antibody production. Nanoparticle-based intradermal antigen delivery may therefore provide a new option in the global effort to develop an effective vaccine against HIV-1.

References

Jul 20, 1999·The Journal of Clinical Investigation·M V DhodapkarN Bhardwaj
Sep 1, 2000·International Journal of Pharmaceutics·W Wang
Jun 19, 2002·The Journal of Clinical Investigation·Ralph M Steinman, Melissa Pope
Aug 21, 2002·The Journal of Experimental Medicine·F GeissmannJ Davoust
Aug 23, 2002·The Journal of Investigative Dermatology·Vincent Piguet, Andrew Blauvelt
Mar 15, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sai T ReddyMelody A Swartz
Dec 16, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Harvinder S Gill, Mark R Prausnitz
Sep 18, 2007·Nature Biotechnology·Sai T ReddyJeffrey A Hubbell
Oct 24, 2007·Trends in Immunology·Vincent Piguet, Ralph M Steinman
May 20, 2008·Vaccine·Paul Henri Lambert, Philippe E Laurent
Aug 19, 2011·Nature·Laura M WalkerPascal Poignard
Dec 16, 2011·The Journal of Investigative Dermatology·Christelle LiardBéhazine Combadière
Apr 6, 2012·The New England Journal of Medicine·Barton F HaynesJerome H Kim
Jan 15, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Rosalind H E ChongJames C Birchall
Feb 8, 2013·Nature Medicine·Hendrik StreeckShane Crotty
Jan 5, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fiorenza RancanAnnika Vogt
Mar 5, 2014·Nature·Nicole A Doria-RoseJohn R Mascola
Aug 6, 2014·Current Opinion in HIV and AIDS·Vincent PiguetAnne Hosmalin

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Citations

Oct 25, 2016·The Journal of Investigative Dermatology·Stephan M Caucheteux, Vincent Piguet
Jan 8, 2017·Annual Review of Pharmacology and Toxicology·Michael R Yeaman, John P Hennessey
Aug 21, 2018·Cellular Microbiology·Rebecca J Bayliss, Vincent Piguet
Jun 9, 2019·The Journal of Pharmacology and Experimental Therapeutics·Rohan S J Ingrole, Harvinder Singh Gill
Jun 30, 2019·Advanced Materials·C Wyatt ShieldsSamir Mitragotri
Jul 28, 2017·Therapeutic Advances in Infectious Disease·Lavanya SinghRaveen Parboosing
Jan 10, 2021·Journal of Clinical Medicine·Vahid AlimardaniSamad Ahadian
May 1, 2021·Micromachines·Ipshita MenonSusu M Zughaier
Sep 29, 2017·Bioconjugate Chemistry·Hamilton KakwereKatherine W Ferrara
Oct 24, 2021·International Journal of Pharmaceutics·Maria TsakiriCostas Demetzos

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