PMID: 6159589Sep 25, 1980Paper

Polypurine DNAs and RNAs form secondary structures which may be tetra-stranded

Nucleic Acids Research
J S LeeA R Morgan

Abstract

Polypurine DNAs and RNAs containing at least 33% guanine form a stable secondary structure at neutral pH and moderate ionic strengths. The tm's of the polymers increase with increasing guanine content. To eliminate possible structures three novel polymers, d(Gn2A)n, d(Gm6A)n and d(IA)n, as well as the random copolymer rr(G,A)n were were studied. Both d(Gn2A)n and d(IA)n can form a secondary structure whereas d(Gm6A)n and r(G,A)n cannot. Model building suggested two possible structures, one a duplex and the other a tetra-stranded polymer. The latter is considered to be the more likely, since previous X-ray diffraction studies have shown that rGn and rIn are tetra-stranded. Circular dichroism spectra are also consistent with such an interpretation.

References

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Citations

Feb 6, 2003·International Journal of Biological Macromolecules·Luigi PetracconeConcetta Giancola
Jan 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·N BaranH Manor
Dec 1, 1990·Journal of Biomolecular Structure & Dynamics·W GuschlbauerD Thiele
Feb 1, 1993·Journal of Biomolecular Structure & Dynamics·S A StreltsovO V Moroz
Dec 2, 1998·Journal of Biomolecular Structure & Dynamics·M Ortiz-LombardíaF Azorín
Sep 25, 1995·Nucleic Acids Research·T SudaR Kominami
Dec 24, 1998·Nucleic Acids Research·M VorlíckováJ Kypr
Jan 1, 1989·International Reviews of Immunology·B D Stollar
Oct 7, 1985·FEBS Letters·J S LeeM L Woodsworth
Oct 26, 1993·Biochemistry·G Awang, D Sen
Sep 1, 1982·Journal of Molecular Biology·D H Evans, A R Morgan
Aug 8, 2007·Biopolymers·Jaroslav KyprMichaela Vorlícková
Nov 7, 1998·The Journal of Biological Chemistry·M N WeitzmannK Usdin
Apr 8, 2003·European Biophysics Journal : EBJ·Jaroslav KyprMichaela Vorlícková
Sep 30, 1988·Science·H Htun, J E Dahlberg

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