Polypyridyl-Based Copper Phenanthrene Complexes: A New Type of Stabilized Artificial Chemical Nuclease

Chemistry : a European Journal
Nicoló Zuin FantoniAndrew Kellett

Abstract

The building of robust and versatile inorganic scaffolds with artificial metallo-nuclease (AMN) activity is an important goal for bioinorganic, biotechnology, and metallodrug research fields. Here, a new type of AMN combining a tris-(2-pyridylmethyl)amine (TPMA) scaffold with the copper(II) N,N'-phenanthrene chemical nuclease core is reported. In designing these complexes, the stabilization and flexibility of TPMA together with the prominent chemical nuclease activity of copper 1,10-phenanthroline (Phen) were targeted. A second aspect was the opportunity to introduce designer phenazine DNA intercalators (e.g., dipyridophenazine; DPPZ) for improved DNA recognition. Five compounds of formula [Cu(TPMA)(N,N')]2+ (where N,N' is 2,2-bipyridine (Bipy), Phen, 1,10-phenanthroline-5,6-dione (PD), dipyridoquinoxaline (DPQ), or dipyridophenazine (DPPZ)) were developed and characterized by X-ray crystallography. Solution stabilities were studied by continuous-wave EPR (cw-EPR), hyperfine sublevel correlation (HYSCORE), and Davies electron-nuclear double resonance (ENDOR) spectroscopies, which demonstrated preferred geometries in which phenanthrene ligands were coordinated to the copper(II) TPMA core. Complexes with Phen, DPQ, and DPPZ ligan...Continue Reading

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Citations

Oct 28, 2019·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Stephen BarrettDiego Montagner
Nov 30, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zara MolphyAndrew Kellett
Jun 11, 2020·Chemistry : a European Journal·Nicoló Zuin FantoniAndrew Kellett
Jul 25, 2020·Chemistry : a European Journal·Teresa LauriaAndrew Kellett
Aug 6, 2020·Chembiochem : a European Journal of Chemical Biology·Nicolò Zuin FantoniAndrew Kellett
Feb 23, 2021·Computers in Biology and Medicine·G PontrelliC Chatgilialoglu
Mar 13, 2021·International Journal of Pharmaceutics·Jacinta O PinhoM Manuela Gaspar
Feb 12, 2021·Chembiochem : a European Journal of Chemical Biology·Nicolò Zuin FantoniAndrew Kellett
Apr 29, 2021·ChemistryOpen·Gulshan R WalkeSharon Ruthstein
Sep 28, 2021·Nucleic Acids Research·Natasha McStayAndrew Kellett
Jan 11, 2022·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Anna Clara Milesi GaldinoAndré Luis Souza Dos Santos

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