Polypyrrole-chitosan conductive biomaterial synchronizes cardiomyocyte contraction and improves myocardial electrical impulse propagation

Theranostics
Zhi CuiRen-Ke Li

Abstract

Background: The post-myocardial infarction (MI) scar interrupts electrical impulse propagation and delays regional contraction, which contributes to ventricular dysfunction. We investigated the potential of an injectable conductive biomaterial to restore scar tissue conductivity and re-establish synchronous ventricular contraction. Methods: A conductive biomaterial was generated by conjugating conductive polypyrrole (PPY) onto chitosan (CHI) backbones. Trypan blue staining of neonatal rat cardiomyocytes (CMs) cultured on biomaterials was used to evaluate the biocompatibility of the conductive biomaterials. Ca2+ imaging was used to visualize beating CMs. A cryoablation injury rat model was used to investigate the ability of PPY:CHI to improve cardiac electrical propagation in the injured heart in vivo. Electromyography was used to evaluate conductivity of scar tissue ex vivo. Results: Cell survival and morphology were similar between cells cultured on biomaterials-coated and uncoated-control dishes. PPY:CHI established synchronous contraction of two distinct clusters of spontaneously-beating CMs. Intramyocardial PPY:CHI injection into the cryoablation-induced injured region improved electrical impulse propagation across the scar...Continue Reading

Citations

Apr 4, 2019·Advanced Healthcare Materials·Kristina Fidanovski, Damia Mawad
Apr 7, 2019·Biotechnology and Applied Biochemistry·Mostafa Cheraghi, Ali Pooria
Dec 13, 2019·Journal of Receptor and Signal Transduction Research·Yunpeng TianHaoming Song
Dec 21, 2019·Journal of Receptor and Signal Transduction Research·Yang YangZhiyun Wang
Jan 29, 2020·Journal of Receptor and Signal Transduction Research·Peng LiQiuyun Tu
Feb 9, 2020·Journal of Biomedical Materials Research. Part a·Payam BaeiSara Pahlavan
Sep 17, 2020·Journal of Drug Targeting·Cuican LiZhou Xiaohui
Sep 18, 2020·Advanced Healthcare Materials·Yu SongLin Wang
Jul 18, 2020·Frontiers in Neuroscience·Jiayan JinYuan Gao
Feb 2, 2019·World Journal of Stem Cells·Pranav Machiraju, Steven C Greenway
Aug 23, 2020·International Journal of Molecular Sciences·Saltanat SmagulArman Saparov
Nov 23, 2019·Journal of Receptor and Signal Transduction Research·Guanqun Ma, Yingwu Liu
Oct 22, 2020·International Journal of Molecular Sciences·Lin JiangYigang Wang
Oct 25, 2020·Stem Cell Reviews and Reports·Pallavi PushpMukesh Kumar Gupta
Jan 10, 2020·Advanced Drug Delivery Reviews·Yimu ZhaoMilica Radisic
Dec 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Adam Chyzy, Marta E Plonska-Brzezinska
Feb 26, 2021·Pflügers Archiv : European journal of physiology·Kalina AndrysiakJózef Dulak
Apr 6, 2021·Bioactive Materials·Yujun ZengKui Luo
Apr 23, 2021·Acta Biomaterialia·Yimeng LiLu Wang
Aug 28, 2021·International Journal of Molecular Sciences·Arsalan Ul HaqPaolo Di Nardo
Aug 30, 2021·Acta Biomaterialia·Hamid EsmaeiliMehdi Nikkhah
Sep 29, 2021·Chemical Reviews·Anna MarianoFrancesca Santoro
Oct 2, 2021·Nature Biomedical Engineering·Leyu WangXiaozhong Qiu
Dec 16, 2021·Chemical Reviews·Charalampos PitsalidisRóisín M Owens

❮ Previous
Next ❯

Methods Mentioned

BETA
enzymatic dissociation
dissecting
coronary artery ligation

Software Mentioned

Origin
ImageJ
BV Analyze
LabChart
Element BR
NIS
Manager
Excel
PowerLab

Related Concepts

Related Feeds

Cardiotoxicity

Cardiotoxicity refers to the muscle damage or dysfunction of heart electrophysiology caused by drug intake or due to disease complications. It is a well-known side effect of several cytotoxic drugs, especially of the anthracyclines and can lead to long term morbidity. Here is the latest research.