Poly[(R)-3-hydroxybutyrate] production under different salinity conditions by a novel Bacillus megaterium strain

New Biotechnology
A Rodríguez-ContrerasM S Marqués-Calvo

Abstract

Bacillus megaterium uyuni S29, isolated from the Bolivian salt lake Uyuni, displays a high capability to produce poly[(R)-3-hydroxybutyrate] (PHB) in industrial culture media. In order to analyze the influence of salt on biomass formation and PHB production, cultivations at different NaCl concentrations were carried out according to the salinity conditions of the habitats of the strain's original isolation. In this preliminary report, the strain showed considerable adaptability to media of different salinity, obtaining the best results for both cellular growth and PHB production in media containing 45g/L NaCl. The strain grew at 100g/L NaCl and PHB production was observed even at high salt levels of 250g/L without unwanted concurrent spore formation. Its tolerance to high salt concentrations together with auspicious PHB productivity makes this strain appealing not only for PHB production, but also for other biotechnological applications such as the treatment of salty wastewater; additional studies will be needed to further increase PHB productivity.

References

Mar 27, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·J M WoodL T Smith
May 1, 2008·Microbial Cell Factories·Senthilkumar SivaprakasamSusheela Rajakumar
Feb 17, 2009·Systematic and Applied Microbiology·Stephanie A SmithRonald L Crawford
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Dec 22, 2009·Applied Microbiology and Biotechnology·Jorge QuillaguamánRajni Hatti-Kaul
Jan 31, 2013·Journal of Applied Microbiology·A Rodríguez-ContrerasM S Marqués-Calvo
Dec 3, 2014·Biotechnology Advances·Jin YinGuo-Qiang Chen

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Citations

Jul 13, 2016·Applied Microbiology and Biotechnology·Hong WuGuo-Qiang Chen
Jan 18, 2019·Biotechnology and Applied Biochemistry·Suguna PonnusamyShenbagarathai Rajaiah
Sep 28, 2017·Bioengineering·Constantina KourmentzaMaria A M Reis
Jan 20, 2021·Bioresource Technology·Parthiba Karthikeyan Obulisamy, Sanjeet Mehariya
Feb 5, 2021·Bioresource Technology·Stanislav ObrucaMartin Koller
Aug 15, 2017·New Biotechnology·Alicia PazJosé Manuel Domínguez

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