Polyrotaxane-based supramolecular theranostics

Nature Communications
Guocan YuXiaoyuan Chen

Abstract

The development of smart theranostic systems with favourable biocompatibility, high loading efficiency, excellent circulation stability, potent anti-tumour activity, and multimodal diagnostic functionalities is of importance for future clinical application. The premature burst release and poor degradation kinetics indicative of polymer-based nanomedicines remain the major obstacles for clinical translation. Herein we prepare theranostic shell-crosslinked nanoparticles (SCNPs) using a β-cyclodextrin-based polyrotaxane (PDI-PCL-b-PEG-RGD⊃β-CD-NH2) to avoid premature drug leakage and achieve precisely controllable release, enhancing the maximum tolerated dose of the supramolecular nanomedicines. cRGDfK and perylene diimide are chosen as the stoppers of PDI-PCL-b-PEG-RGD⊃β-CD-NH2, endowing the resultant SCNPs with excellent integrin targeting ability, photothermal effect, and photoacoustic capability. In vivo anti-tumour studies demonstrate that drug-loaded SCNPs completely eliminate the subcutaneous tumours without recurrence after a single-dose injection combining chemotherapy and photothermal therapy. These supramolecular nanomedicines also exhibit excellent anti-tumour performance against orthotopic breast cancer and prevent lu...Continue Reading

References

Mar 17, 2001·Advanced Drug Delivery Reviews·K KataokaY Nagasaki
Jul 11, 2003·Nature·David A LeighFrancesco Zerbetto
Oct 2, 2003·Nature Biotechnology·David A LaVanRobert Langer
Apr 2, 2004·Nature·Robert Langer, David A Tirrell
Nov 24, 2004·Angewandte Chemie·Norased NasongklaJinming Gao
Mar 2, 2005·Nature Reviews. Cancer·Mauro Ferrari
Jul 26, 2008·Nature Nanotechnology·Dan PeerRobert Langer
Jul 10, 2010·Nature Reviews. Drug Discovery·Robby A Petros, Joseph M DeSimone
Jul 22, 2010·Angewandte Chemie·Katrin KnopUlrich S Schubert
Jun 17, 2011·Accounts of Chemical Research·Michael W AmbrogioJ Fraser Stoddart
Oct 6, 2011·Chemical Reviews·Yu-Fang WangBin Cong
Jan 5, 2012·Chemical Society Reviews·Zongxi LiJeffrey I Zink
Apr 13, 2013·Chemical Reviews·Min Hee LeeJong Seung Kim
May 22, 2013·Journal of the American Chemical Society·Qiwei TianXiaogang Liu
May 9, 2014·Nature Communications·Ran NamgungWon Jong Kim
Sep 27, 2014·Chemical Reviews·Liang ChengZhuang Liu
Oct 8, 2014·Nature Reviews. Drug Discovery·Vladimir P Torchilin
Jan 31, 2015·Accounts of Chemical Research·Xiaolian SunXiaoyuan Chen
May 23, 2015·Chemical Reviews·Guosong HongHongjie Dai
Jun 30, 2015·Chemical Society Reviews·Rajesh KumarJong Seung Kim
Oct 16, 2015·Chemical Reviews·Mahmoud ElsabahyKaren L Wooley
Dec 22, 2016·Bioconjugate Chemistry·Qingqing Miao, Kanyi Pu
May 1, 2016·Chemical Science·Guocan YuFeihe Huang

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Citations

Jul 6, 2018·Chemical Communications : Chem Comm·Dan WuGuocan Yu
Jul 20, 2018·Chemistry : a European Journal·Scott K ShawBradley D Smith
Sep 28, 2018·Chemical Society Reviews·Yijing LiuXiaoyuan Chen
Dec 18, 2018·Advanced Materials·Qinrui FuXiaoyuan Chen
Aug 30, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Beng YangShusen Zheng
Jul 9, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qiang SunMengjie Wu
Jul 11, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yong GaoZhengwei Mao
May 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Bing WangChangyou Gao
Oct 3, 2018·Chemical Communications : Chem Comm·Xianqiang ZengJianhui Fang
Sep 13, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Thomas EbenhanMike Sathekge
Dec 19, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Byunghee HwangYoungmi Kim
Feb 2, 2021·Chemical Society Reviews·Jiong ZhouFeihe Huang
Dec 3, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yurii ShepelytskyiMitchell S Albert
Apr 28, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jinlei PengHua Wei
Nov 5, 2020·Current Opinion in Chemical Biology·Guocan YuXiaoyuan Chen
Jun 20, 2021·Advanced Science·Jiating XuYujie Fu
Jul 16, 2021·National Science Review·Xiang LingQianjun He
Jul 8, 2021·Chemical Communications : Chem Comm·Junjun WanXuzhou Yan
May 29, 2020·Journal of the American Chemical Society·Kang CaiJ Fraser Stoddart
Apr 13, 2019·Accounts of Chemical Research·Zhen Yang, Xiaoyuan Chen
Jul 12, 2018·ACS Applied Materials & Interfaces·Chen SunRuibing Wang

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Methods Mentioned

BETA
fluorescence imaging
NMR
X-ray
transmission electron microscopy
AFM
atomic force microscopy
flow cytometry
xenograft
xenografts

Software Mentioned

Inveon

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