Polysaccharide-Based pH-Responsive Nanocapsules Prepared with Bio-Orthogonal Chemistry and Their Use as Responsive Delivery Systems.

Biomacromolecules
Mohammad Shafee AlkanawatiHéloïse Thérien-Aubin

Abstract

Bio-orthogonal reactions have become an essential tool to prepare biomaterials; for example, in the synthesis of nanocarriers, bio-orthogonal chemistry allows circumventing common obstacles related to the encapsulation of delicate payloads or the occurrence of uncontrolled side reactions, which significantly limit the range of potential payloads to encapsulate. Here, we report a new approach to prepare pH-responsive nanocarriers using dynamic bio-orthogonal chemistry. The reaction between a poly(hydrazide) crosslinker and functionalized polysaccharides was used to form a pH-responsive hydrazone network. The network formation occurred at the interface of aqueous nanodroplets in miniemulsion and led to the production of nanocapsules that were able to encapsulate payloads of different molecular weights. The resulting nanocapsules displayed low cytotoxicity and were able to release the encapsulated payload, in a controlled manner, under mildly acidic conditions.

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Citations

Sep 6, 2020·Polymers·Joanna Szafraniec-SzczęsnySzczepan Zapotoczny
Jun 16, 2021·Biomacromolecules·Mohammad Shafee AlkanawatiHéloïse Thérien-Aubin
Sep 25, 2021·ACS Applied Materials & Interfaces·Zhijuan SunJintao Yang

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Methods Mentioned

BETA
fluorescence spectroscopy
flow
fluorescence microscopy
flow cytometry

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