Abstract
Immunity due to immune balance contributes to disease prevention and treatment. Radix Codonopsis polysaccharide (RCP) is isolated from the root of the Chinese herb Codonopsis pilosula. Previous studies have indicated that RCP has immunomodulatory activities; however, the effects of RCP on immunity, especially immune balance, are still largely unknown. In the present study, we investigated the effects of RCP on T-cell balance in mice. The mice were pretreated intragastrically with or without RCP for 15 days and injected with hydrocortisone on days 10-15 to disturb the immune system. The spleen and thymus were weighed and used to calculate immune organ indexes. The percentages of CD4+ T cells, CD8+ T cells, Th1 cells, Th2 cells, regulatory T cells (Tregs) and Th17 cells in peripheral blood were assayed by flow cytometry. Pro-inflammatory and anti-inflammatory cytokines, TNF-α, IL-1β and IL-10, in serum were determined by enzyme-linked immunosorbent assay (ELISA) kits. The results showed that RCP pretreatment could maintain the homeostasis of CD8+ T cells, Tregs, Th17 cells, TNF-α, IL-1β and IL-10 in hydrocortisone-treated mice. Furthermore, RCP pretreatment maintained the immune balance of CD4+/CD8+ T cells, Th1/Th2 cells, Tregs/...Continue Reading
References
Dec 1, 1996·General Pharmacology·Z T WangG J Xu
Jun 25, 1999·Scandinavian Journal of Rheumatology·N MaedaS Hirose
Aug 23, 2002·Immunological Reviews·J F A P Miller
Aug 23, 2002·Leukemia Research·Michiaki KoikeKazuo Oshimi
Mar 4, 2003·Nature Immunology·Jason D FontenotAlexander Y Rudensky
Oct 1, 1962·Analytical Biochemistry·T BITTER, H M MUIR
Oct 13, 2006·Archives of Neurology·Olaf StüveMichael K Racke
Jan 24, 2007·Nature Immunology·Thomas Boehm, Conrad C Bleul
May 31, 2008·Cell·Shimon SakaguchiMasahiro Ono
Jul 22, 2008·International Journal of Biological Macromolecules·Sun Yongxu, Liu Jicheng
Jan 10, 2009·Annual Review of Immunology·Thomas KornVijay K Kuchroo
May 30, 2009·Journal of Leukocyte Biology·Aiping BaiZhikang Peng
Jun 25, 2009·Chemistry & Biodiversity·Yong-Xu Sun
Sep 19, 2009·Immunologic Research·Xuefang Cao
Nov 26, 2009·Journal of Clinical Immunology·Nicola Eastaff-LeungSimon Barry
Jan 5, 2011·Cellular & Molecular Immunology·Walayat ShahYili Wang
Sep 20, 2012·Nature Immunology·Romina S Goldszmid, Giorgio Trinchieri
Apr 12, 2013·Pigment Cell & Melanoma Research·Mitesh DwivediRasheedunnisa Begum
Jul 13, 2013·Food & Function·Lv YingjianLi Zhi
Jan 1, 2012·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Yongzhan BaoWanyu Shi
Nov 19, 2013·Immunity·Vincenzo Bronte, Mikael J Pittet
Dec 4, 2013·Shock·Yi-shan ZhengJie-shou Li
May 3, 2014·International Immunopharmacology·Ning-fei JiMao Huang
Mar 13, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Pou Kuan LeongKam Ming Ko
Feb 14, 2016·International Immunology·Kiyoshi Hirahara, Toshinori Nakayama
Mar 15, 2016·Scientific Reports·Matthew J OlnesUNKNOWN CHI Consortium
Jul 12, 2016·Nature Reviews. Immunology·Gérard Eberl
Jul 31, 2016·BMC Gastroenterology·Mingming ZhangChenggong Yu
Oct 22, 2016·Environmental Toxicology and Pharmacology·Xu ChuJuan Shu
Jul 6, 2017·Journal of Autoimmunity·Massimo GadinaYasuko Furumoto
Jul 18, 2017·Journal of Autoimmunity·Marjorie ArgolloSilvio Danese
Aug 11, 2017·Medicine·Yong-Ting LanKai Wang
May 1, 2018·Journal of Thoracic Disease·Xiaoxia LuQing Du
May 29, 2018·The Journal of Surgical Research·Triantafyllos DouliasIoannis M Koutelidakis
Jul 25, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yu-Ping FuYuan-Feng Zou
Citations
Jul 2, 2020·Food & Function·Qi XieChanghong Wang
Jul 12, 2020·Aging·Lu WanXiaochuan Wang
Feb 18, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Houpan SongQinghua Peng
Dec 29, 2020·Frontiers in Pharmacology·Xuelian XiangWanyan Li
Dec 20, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yajie WangTonghua Yang
Jan 19, 2021·Science Bulletin·Yifei DaiDong Wang
Nov 15, 2020·Trials·Ning Yi YapAlexandre Chan
Nov 15, 2020·BMC Complementary Medicine and Therapies·Bo LiangNing Gu
Mar 27, 2021·Carbohydrate Polymers·Fei LuanNan Zeng
Mar 17, 2020·Carbohydrate Polymers·Qiannian WuLan Yu