Polysaccharide K and Coriolus versicolor extracts for lung cancer: a systematic review

Integrative Cancer Therapies
Heidi FritzDugald Seely

Abstract

Polysaccharide K, also known as PSK or Krestin, is derived from the Coriolus versicolor mushroom and is widely used in Japan as an adjuvant immunotherapy for a variety of cancer including lung cancer. Despite reported benefits, there has been no English language synthesis of PSK for lung cancer. To address this knowledge gap, we conducted a systematic review of PSK for the treatment of lung cancer. We searched PubMed, EMBASE, CINAHL, the Cochrane Library, AltHealth Watch, and the Library of Science and Technology from inception to August 2014 for clinical and preclinical evidence pertaining to the safety and efficacy of PSK or other Coriolus versicolor extracts for lung cancer. Thirty-one reports of 28 studies were included for full review and analysis. Six studies were randomized controlled trials, 5 were nonrandomized controlled trials, and 17 were preclinical studies. Nine of the reports were Japanese language publications. Fifteen of 17 preclinical studies supported anticancer effects for PSK through immunomodulation and potentiation of immune surveillance, as well as through direct tumor inhibiting actions in vivo that resulted in reduced tumor growth and antimetastatic effects. Nonrandomized controlled trials showed impro...Continue Reading

References

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Citations

Mar 13, 2016·Food & Nutrition Research·Ana B BarrosTito Fernandes
Jun 25, 2016·Applied Microbiology and Biotechnology·Tzi Bun NgWai Yee Chan
Mar 22, 2018·Integrative Cancer Therapies·Dugald SeelyLinlu Zhao
Sep 25, 2018·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Moshe FrenkelVictor Sierpina
Jul 22, 2017·Current Medicinal Chemistry·Jack Ho WongHelen Chan
Jan 11, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Marilene FilbetAmie Steel
Oct 11, 2017·Chinese Journal of Integrative Medicine·Wei-Ling PuMargaret Gebauer
Jul 26, 2019·Veterinary Sciences·Shiori AraiEtienne Côté
Jan 14, 2021·International Journal of Molecular Sciences·Giuseppe VenturellaMaria Letizia Gargano
Jul 23, 2020·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Mateusz WinderJerzy Chudek

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Methods Mentioned

BETA
bronchoalveolar lavage

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