Polysaccharide of Atractylodes macrocephala Koidz regulates LPS-mediated mouse hepatitis through the TLR4-MyD88-NFκB signaling pathway.

International Immunopharmacology
Sixuan GuoNan Cao

Abstract

Feed corruption and poor breeding environment could cause widespread bacterial infection which could cause severe liver inflammation and lead to liver damage, even death. It has been proved that Polysaccharide of Atractylodes macrocephala Koidz (PAMK) could improve the immunity of animal, but the mechanism of its protective effect on hepatitis has been rarely reported. This study investigated the protective effect of PAMK on mouse liver through LPS-induced liver inflammatory. The results showed that LPS caused swelling of hepatocytes, disappearance of hepatic cord structure and infiltration of a large number of inflammatory cells, and LPS could up-regulated mRNA and protein expression levels of TLR4, MyD88, IKBα and NFκB, increased cytokines IL-1β, IL-4, IL-6 and TNF-α levels, enhance the levels of antioxidant enzymes CAT, GSH-PX, SOD, iNOs and MDA. PAMK pretreatment could relieved histopathological damage caused by LPS, and could activate the TLR4-MyD88-NFκB signalling pathway, reduce the levels of IL-1β, IL-6 and TNF-α, increase IL-4 levels, inhibit the levels of GSH-PX and MDA. These results indicate that PAMK could reduce inflammatory damage and oxidative stress in mice and play a protective role in the early stages of LPS ...Continue Reading

References

Aug 30, 2000·Nature·A Aderem, R J Ulevitch
Sep 16, 2010·Free Radical Biology & Medicine·Simone ReuterBharat B Aggarwal
Jan 14, 2011·Journal of Gastroenterology and Hepatology·Hartmut Jaeschke
Jul 16, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mi Jeong ParkSang-Bae Han
Oct 22, 2014·Cellular and Molecular Life Sciences : CMLS·Agnieszka PłóciennikowskaKatarzyna Kwiatkowska
Dec 3, 2014·International Journal of Biological Macromolecules·Jie LiuYuanliang Hu
Jan 29, 2016·International Journal of Biological Macromolecules·Bing HanJin Pei
Aug 23, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiaoya ShangWeining Niu
Dec 29, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·An-Jun LiuHui-Ping Liu
Feb 11, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Patrick Marcellin, Blaise K Kutala
Aug 26, 2018·International Journal of Biological Macromolecules·Zhenguang LiuDeyun Wang
Sep 10, 2018·Neurochemistry International·Xiao ChengYaping Wang
Apr 30, 2019·Progress in Molecular Biology and Translational Science·Zhihua GuoLijuan Zhang
Jun 22, 2019·International Journal of Biological Macromolecules·Ying-Ying FengAn-Jun Liu
Oct 12, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ke LiYuguang Du

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Citations

Aug 15, 2021·Bioorganic & Medicinal Chemistry Letters·Shiyang ZhouJian Liu

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