Abstract
Polysaccharide peptide (PSP) is a protein-bound polysaccharide extracted from an edible mushroom, Coriolus versicolor. Effects of PSP (2g/kg/day) on cyclophosphamide (CPA, 40 mg/kg/2 days)-induced immunosuppression were investigated by determining lymphocyte proliferation, Natural killer (NK) cell formation, IgG and IL-2 concentration, WBC count and the weight of organs after rats were treated with or without CPA in the presence or absence of PSP. The results demonstrated that PSP possessed immunopotentiating effect, being effective in restoring CPA-induced immunosuppression such as depressed lymphocyte proliferation, Natural Killer cell function, production on white blood cell and the growth of spleen and thymus in rats as well as in increasing both IgG and IL-2 production on which CPA did not have significant effects under the conditions of our experiments. PSP can partly restore CPA-induced immunosuppression. Based on our findings and the data accumulated so far, it was suggested that PSP should be considered as an useful adjuvant especially combined with CPA or other chemotherapy in clinical treatment of cancer patients. The mechanism by which PSP restores the immunosuppression induced by CPA is unclear.
Citations
Feb 24, 2007·Journal of Industrial Microbiology & Biotechnology·Jian CuiHarjinder Singh
Mar 5, 2004·International Immunopharmacology·C K WongC W K Lam
Jun 20, 2002·Life Sciences·Jingsong ZhangHua Fan
Sep 23, 2003·Biotechnology Advances·Jian Cui, Yusuf Chisti
Oct 13, 2006·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Yi Xi BaoChristopher Wai Kei Lam
Dec 17, 2009·Hematology·Daniel Man-Yuen Sze, Godfrey Chi-Fung Chan
Aug 5, 2014·Journal of Thermal Biology·Tomasz JedrzejewskiWieslaw Kozak
May 30, 2014·The American Journal of Chinese Medicine·Willmann LiangPing Chung Leung
Sep 8, 2004·International Immunopharmacology·C Y HoMoses S S Chow
Jun 9, 2004·Life Sciences·C B S LauM S S Chow
Dec 12, 2012·Carbohydrate Polymers·Wen-kuang HsuJohn Po-wen Yang
Mar 4, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Lj HarhajiS Stosić-Grujicić
Sep 1, 2012·Carbohydrate Polymers·John Powen YangYucheng Chen
Jun 20, 2003·Respiratory Medicine·K W TsangW K Lam
May 2, 2003·The American Journal of Chinese Medicine·Louis W C ChowJonathan S T Sham
Jul 29, 2005·The American Journal of Chinese Medicine·Chun-Kwok WongChristopher Wai Kei Lam
Aug 8, 2008·Immunopharmacology and Immunotoxicology·Jin LiHongping Wang
Feb 6, 2010·Immunopharmacology and Immunotoxicology·Wenwen LiYixi Bao
May 21, 2011·Pharmaceutical Biology·Janet Yuen-Yan ChanIvan Ying-Ming Chung
Sep 5, 2019·Nutrients·Masataka UchidaMotoyuki Iemitsu
May 30, 2020·Biomedicines·Solomon Habtemariam
Jul 30, 2020·Chinese Medicine·Chun Sing LamZhong Zuo
Sep 22, 2017·Frontiers in Immunology·Mohammad H SalehArmand Keating