Polysaccharide with antioxidant, α-amylase inhibitory and ACE inhibitory activities from Momordica charantia

International Journal of Biological Macromolecules
Hwee-Feng Tan, Chee-Yuen Gan

Abstract

Functional polysaccharide was isolated from Momordica charantia, with a yield of 36% (w/w). M. charantia bioactive polysaccharide (MCBP) was an acidic and branched heteropolysaccharide with a molecular weight of 92 kDa. Fourier transform infrared spectroscopic analysis indicated that MCBP was a pectin-like polysaccharide with an esterification degree of 53% and it contains numerous monosaccharides, predominantly glucose, galactose, and galaturonic acid. The results also showed that MCBP exhibited free radical scavenging activity (31.9%), ferric reducing antioxidant power (0.95 mM), α-amylase inhibition (89.1%), and angiotensin-converting enzyme inhibition (94.1%). In the terms of functionality, MCBP showed a lower water-holding capacity but higher in oil-holding capacity, emulsifying activity and foaming capacity compared to citrus pectin. Scanning electron microscopy images demonstrated that MCBP formed gels with a porous structure, and flow analysis showed that the gel solution exhibited pseudoplastic shear-thinning behavior. These findings indicated that MCBP is a promising functional macromolecular carbohydrate for the food and nutraceutical industries.

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Citations

Jul 6, 2016·International Journal of Biological Macromolecules·Fan ZhangJianhua Xie
Dec 13, 2016·International Journal of Biological Macromolecules·Shuhong LiZhenya Zhang
Nov 29, 2017·International Journal of Molecular Sciences·Shuo JiaJianhua Xie
May 14, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Leila SouaSemia Ellouz Chaabouni
May 30, 2019·Frontiers in Pharmacology·Massimo BortolottiLetizia Polito
Jan 30, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Zhuo LiuHui Dong
Feb 12, 2019·International Journal of Biological Macromolecules·Ilhem RjeibiGuillaume Pierre
Jul 7, 2021·International Journal of Biological Macromolecules·Miaotian XieYicun Chen

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