Polysaccharides as excipients for colon-specific coatings. Permeability and swelling properties of casted films

Drug Development and Industrial Pharmacy
Osvaldo Albuquerque CavalcantiRenaat Kinget

Abstract

Oligosaccharides such as inulin (In) and polysaccharides such as galactomannans, combined with polymethacrylates on isolated films for film coatings, were obtained from aqueous-based solvents and investigated as potential vehicles for colonic drug delivery. These compositions, which are susceptible to fermentation by colonic microflora, constitute promising excipients for the development of new colon-specific therapeutic systems. The characteristics of several compositions have been demonstrated in permeability and swelling studies on isolated films composed of a polymethacrylate associated with In or galactomannans of mesquite seed gum (MSG). Results reported prove a dependency of the properties of mixed films on the polymethacrylate-polysaccharide concentration ratio and on the composition of the dissolution media. An increase in permeability through the mixed films was observed in a simulated colonic environment for the following compositions: Eudragit RS30D-MSG 70:30 w/w; Eudragit RS30D-In 90:10 w/w; Eudragit RS30D-In 76:24 w/w.

References

Apr 1, 1974·Journal of Pharmaceutical Sciences·G L FlynnT J Roseman
Jan 1, 1996·Critical Reviews in Therapeutic Drug Carrier Systems·L Hovgaard, H Brøndsted
Aug 1, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·Y V PrasadS Satyanarayana
Aug 4, 1998·Pharmaceutical Research·I Gliko-KabirA Rubinstein
Jan 14, 1999·Journal of Drug Targeting·R KingetG van den Mooter
May 11, 1999·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·M WesselingR Bodmeier
Jun 26, 1999·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·F DamianR Kinget

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Citations

Jun 18, 2015·Drug Development and Industrial Pharmacy·Kieran KeohaneBrendan T Griffin
Dec 10, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Aleksandra M UrbanskaSatya Prakash
Nov 14, 2007·Journal of Materials Science. Materials in Medicine·Valluru RaviT M Pramod Kumar
Jan 1, 2015·International Scholarly Research Notices·Helen ChattopadhyaySriparna Datta
Apr 16, 2017·AAPS PharmSciTech·Suélen Plaza PominOsvaldo Albuquerque Cavalcanti
Oct 16, 2002·World Journal of Gastroenterology : WJG·Yi-Nuo PangZhi-Rong Zhang
Jan 1, 2020·Heliyon·Frederico Minardi de OliveiraOsvaldo Albuquerque Cavalcanti
Sep 3, 2021·Journal of Food Science and Technology·Gabrielle Lázara Ribeiro Rodrigues de Barros VinhalRicardo Stefani

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