Polysaccharides as potential antioxidative compounds for extended-release matrix tablets

Carbohydrate Research
Hisao TomidaMakoto Anraku

Abstract

The objective of this study was to identify polysaccharides with antioxidant properties for use as potential antioxidative compounds for extended-release matrix tablets. The antioxidant properties of five different polysaccharides, high molecular weight alginate (H-ALG), low molecular weight alginate (L-ALG), high molecular weight chitosan (H-chitosan), low molecular weight chitosan (L-chitosan), and pectic acid (PA) were examined using N-centered radicals from 1,1'-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and reducing power, based on their ability to reduce Cu(2+). L-chitosan and PA had acceptable scavenging abilities and were good radical scavengers, with good reducing power, but the H-chitosan and alginate derivatives were much less effective. The results suggest that L-chitosan and PA could be useful in combating oxidative stress. A PA and L-chitosan interpolymer complex (IPC) tablet was prepared and evaluated as an extended-release tablet matrix using theophylline (TPH) as a model drug. The release of TPH from the matrix tablet (TPH/PA/L-chitosan=200 mg:150 mg:50 mg) was slower than that from PA only (TPH/PA/chitosans=200 mg:200 mg:0 mg) or L-chitosan only (TPH/PA/L...Continue Reading

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Citations

Oct 15, 2013·International Journal of Biological Macromolecules·Seyede Marzieh HosseiniRamin Khaksar
Nov 30, 2011·Drug Development and Industrial Pharmacy·Luca CasettariEnzo Castagnino
Feb 24, 2016·Biofouling·Michela Gambino, Francesca Cappitelli
Sep 9, 2015·Journal of Agricultural and Food Chemistry·Francisco Flores-CéspedesManuel Fernández-Pérez
Apr 18, 2015·International Journal of Pharmaceutics·Makoto AnrakuFumitoshi Hirayama
May 7, 2013·International Journal of Biological Macromolecules·Ryogo AbuTatsuya Oda
Oct 13, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vania Urias-OronaAlfonso A Gardea
May 8, 2014·Journal of Analytical Toxicology·Lindsey M MannJoseph D Ma
Jun 27, 2019·Macromolecular Bioscience·Birgit StubbePeter Dubruel
Mar 5, 2021·Journal of Animal Physiology and Animal Nutrition·Mónica CostaJosé A M Prates
Jun 20, 2020·Metabolic Engineering Communications·Diego Tec CamposKarsten Zengler
Oct 20, 2018·International Journal of Biological Macromolecules·Masoumeh ArabAmir Mohammad Mortazavian

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