Polysaccharides from Burkholderia species as targets for vaccine development, immunomodulation and chemical synthesis

Natural Product Reports
Maude CloutierCharles Gauthier

Abstract

Covering: up to 2018 Burkholderia species are a vast group of human pathogenic, phytopathogenic, and plant- or environment-associated bacteria. B. pseudomallei, B. mallei, and B. cepacia complex are the causative agents of melioidosis, glanders, and cystic fibrosis-related infections, respectively, which are fatal diseases in humans and animals. Due to their high resistance to antibiotics, high mortality rates, and increased infectivity via the respiratory tract, B. pseudomallei and B. mallei have been listed as potential bioterrorism agents by the Centers for Disease Control and Prevention. Burkholderia species are able to produce a large network of surface-exposed polysaccharides, i.e., lipopolysaccharides, capsular polysaccharides, and exopolysaccharides, which are virulence factors, immunomodulators, major biofilm components, and protective antigens, and have crucial implications in the pathogenicity of Burkholderia-associated diseases. This review provides a comprehensive and up-to-date account regarding the structural elucidation and biological activities of surface polysaccharides produced by Burkholderia species. The chemical synthesis of oligosaccharides mimicking Burkholderia polysaccharides is described in detail. Em...Continue Reading

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Citations

Feb 11, 2021·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Kevin Muru, Charles Gauthier
Feb 9, 2021·Frontiers in Microbiology·Chalita ChomkatekaewClaire Chewapreecha
Jun 23, 2021·Carbohydrate Research·Nazar HussainCharles Gauthier
Jul 15, 2020·Organic Letters·Oscar Javier Gamboa MarinCharles Gauthier
Oct 12, 2021·Science China. Life Sciences·Yue TangYihua Chen

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Methods Mentioned

BETA
acetylation
atomic force microscopy
NMR
circular dichroism
glycosylation
ELISA
chip
saturation transfer
acylation
electrophoresis

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