Polysaccharides from Enteromorpha prolifera Improve Glucose Metabolism in Diabetic Rats

Journal of Diabetes Research
Wenting LinAoyagi Kiyoshi

Abstract

This study investigated the effects of polysaccharides from Enteromorpha prolifera (PEP) on glucose metabolism in a rat model of diabetes mellitus (DM). PEP (0, 150, 300, and 600 mg/kg) was administered intragastrically to rats for four weeks. After treatment, fasting blood glucose (FBG) and insulin (INS) levels were measured, and the insulin sensitivity index (ISI) was calculated. The morphopathological changes in the pancreas were observed. Serum samples were collected to measure the oxidant-antioxidant status. The mRNA expression levels of glucokinase (GCK) and insulin receptor (InsR) in liver tissue and glucose transporter type 4 (GLUT-4) and adiponectin (APN) in adipose tissue were determined. Compared with the model group, the FBG and INS levels were lower, the ISI was higher, and the number of islet β-cells was significantly increased in all the PEP groups. In the medium- and high-dose PEP groups, MDA levels decreased, and the enzymatic activities of SOD and GSH-Px increased. The mRNA expression of InsR and GCK increased in all the PEP groups; APN mRNA expression increased in the high-dose PEP group, and GLUT-4 mRNA expression increased in adipose tissue. These findings suggest that PEP is a potential therapeutic agent t...Continue Reading

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Citations

May 18, 2016·Carbohydrate Polymers·Peng-Cheng WangHai-Xue Kuang
May 24, 2016·International Journal of Biological Macromolecules·Chuner CaiPeimin He
Jul 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kumar Ganesan, Baojun Xu
Jan 27, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Guopeng LinChao Zhao
Mar 9, 2020·Journal of Molecular Microbiology and Biotechnology·Jin LiZhong Hu

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Methods Mentioned

BETA
ELISA
PCR
MDA
Light
transgenic

Software Mentioned

Image
Pro Plus

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