Polysaccharides from Korean Citrus hallabong peels inhibit angiogenesis and breast cancer cell migration

International Journal of Biological Macromolecules
J Y ParkK S Kang

Abstract

Although the peel of the hallabong (Citrus sphaerocarpa) fruit is rich in polysaccharides, which are valuable dietary ingredients for human health, it is normally wasted. The present study aimed to utilize the peel waste and identify properties it may have against breast cancer metastasis. Hallabong peel extract containing crude polysaccharides was fractionated by gel permeation chromatography to produce four different polysaccharide fractions (HBE-I, -II, -III, and -IV). The HBE polysaccharides significantly blocked tube formation of human umbilical vein vascular endothelial cells (HUVECs), at a concentration of 12.5 or 25 μg/mL. Tube formation appeared to be more sensitive to HBE-II than to other HBE polysaccharides. HBE-II also inhibited breast cancer cell migration, through downregulation of matrix metalloproteinase-9 (MMP-9) in MDA-MB-231 triple-negative breast cancer cells. Therefore, inhibition of tube formation and MMP-9-mediated migration observed in HUVEC and MDA-MB-231 cells, respectively, are likely to be important therapeutic targets in triple-negative breast cancer metastasis.

References

May 9, 2006·Cancer Metastasis Reviews·Elena I Deryugina, James P Quigley
Aug 7, 2009·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Yuka Sasaki, Hitoshi Tsuda
Nov 30, 2011·Current Opinion in Obstetrics & Gynecology·John H Howard, Kirby I Bland

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Citations

Apr 27, 2016·Journal of Agricultural and Food Chemistry·Seoung Rak LeeKi Hyun Kim
Nov 23, 2016·Journal of Medicinal Food·Dae-Young LeeKwang-Soon Shin
Apr 2, 2017·International Journal of Biological Macromolecules·Yana ZhaoAnjun Liu
May 12, 2020·Current Developments in Nutrition·Nooshin KoolajiPeter Valtchev
Jan 16, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Charatda PunvittayagulRawiwan Wongpoomchai
Aug 19, 2020·International Journal of Biological Macromolecules·Teng WangBin Wang
Apr 24, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhidan YuKaoshan Chen

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