Polysaccharides isolated from Cordyceps Sinensis contribute to the progression of NASH by modifying the gut microbiota in mice fed a high-fat diet

PloS One
Lei ChenMintao Zhong

Abstract

Various dietary fibers are considered to prevent obesity by modulating the gut microbiota. Cordyceps sinensis polysaccharide (CSP) is a soluble dietary fiber known to have protective effects against obesity and related diseases, but whether these effects induce any side effects remains unknown. The function and safety of CSP were tested in high-fat diet (HFD)-feding C57BL/6J mice. The results revealed that even though CSP supplementation could prevent an increase in body weight, it aggravated liver fibrosis and steatosis as evidenced by increased inflammation, lipid metabolism markers, insulin resistance (IR) and alanine aminotransferase (ALT) in HFD-induced obesity. 16S rDNA gene sequencing was used to analyze the gut microbiota composition, and the relative abundance of the Actinobacteria phylum, including the Olsenella genus, was significantly higher in CSP-treated mice than in HFD-fed mice. CSP supplementation may increase the proportion of Actinobacteria, which can degrade CSP. The high level of Actinobacteria aggravated the disorder of the intestinal flora and contributed to the progression from obesity to nonalcoholic steatohepatitis (NASH) and related diseases.

References

Oct 25, 2008·Critical Reviews in Food Science and Nutrition·Amaya Aleixandre, Marta Miguel
Dec 22, 2012·Acta Biochimica Et Biophysica Sinica·Xu Xiao, Bao-Liang Song
Aug 6, 2013·Nature Reviews. Microbiology·Liping Zhao
Jan 15, 2014·The British Journal of Nutrition·Gisela A WeissThierry Hennet
Sep 27, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yuan YueHong Ding
Jan 16, 2016·Cell Metabolism·Joan Font-BurgadaMichael Karin
Oct 8, 2016·Food & Function·Son G NguyenTatsuya Unno
Dec 23, 2016·JAMA : the Journal of the American Medical Association·Anthony L Komaroff
Feb 16, 2017·Journal of Pineal Research·Pengfei XuYonggong Zhai
Mar 11, 2017·Cell Host & Microbe·Peter J Turnbaugh
Mar 17, 2017·Advances in Nutrition·Zeinab MokhtariAzita Hekmatdoost
Jul 1, 2017·Gut·Fergus ShanahanCatherine Stanton
Jul 25, 2017·Trends in Microbiology·Nathan D Schwalm, Eduardo A Groisman
Sep 11, 2017·Brain, Behavior, and Immunity·Julieta SchachterJohn D Young
Sep 21, 2017·Trends in Biochemical Sciences·Kavita J Rangan, Howard C Hang
Jan 19, 2018·Molecular Nutrition & Food Research·Guijie ChenYi Sun
Apr 18, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Francesca Romana PonzianiVincenzo Mazzaferro
May 10, 2018·Nature Reviews. Gastroenterology & Hepatology·Susanne SchusterAriel E Feldstein
May 12, 2018·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Tomoko OhashiYoshihiro Ogawa
Jun 15, 2018·Cell Host & Microbe·Kassem MakkiFredrik Bäckhed
Jul 4, 2018·Nature Medicine·Scott L FriedmanArun J Sanyal
Jul 10, 2018·Journal of Agricultural and Food Chemistry·Jinbiao ZhaoXi Ma
Jul 11, 2018·Nature Medicine·Fyodor D Urnov
Aug 31, 2018·Nature Reviews. Gastroenterology & Hepatology·Cyrielle Caussy, Rohit Loomba
Sep 23, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Yongbo KangXiangyang Kong
Sep 29, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Anna PedretRosa Solà

❮ Previous
Next ❯

Methods Mentioned

BETA
protein assay
ELISA
PCR
PCA
16S sequencing

Software Mentioned

Vsearch
Image
GraphPad Prism
MAFFT
ANOVE
Lab
QIIME
FLASH

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Chun-Hung ChiuMei-Chin Mong
Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
I E Timor-TritschG Cali
© 2022 Meta ULC. All rights reserved