PMID: 11933115Apr 5, 2002Paper

Polysaccharides isolated from Echinacea purpurea herba cell cultures to counteract undesired effects of chemotherapy--a pilot study

Phytotherapy Research : PTR
Dieter MelchartReinhard Saller

Abstract

In an open prospective study with matched historical controls we aimed to evaluate whether a polysaccharide fraction isolated from the herb Echinacea purpurea could counteract the undesired effects of chemotherapy. Fifteen patients with advanced gastric cancer undergoing palliative chemotherapy with etoposide, leucovorin and 5-fluorouracil (ELF) received for 10 days (beginning 3 days before chemotherapy) daily i.v. injections of 2 mg of a polysaccharide fraction isolated from Echinacea purpurea herb cell cultures (EPS-EPO VIIa). The median number of leukocytes 14-16 days after chemotherapy was 3630/microL (range 1470-5770) in the patients receiving EPS-EPO VIIa compared with 2370/microL (870-3950) in the patients of the historical control group (p = 0.015). EPS-EPO VIIa had no clinically relevant effects on phagocytic activity of granulocytes or on lymphocyte subpopulations. Sixty-eight adverse events including two deaths were observed, most likely due to chemotherapy and the general condition of the patients. However, an association with the test intervention cannot be ruled out completely. The results of this pilot study suggest that EPS-EPO VIIa might be effective in reducing chemotherapy-induced leukopenia. The efficacy and...Continue Reading

References

May 3, 1989·Journal of the National Cancer Institute·B LuettigM L Lohmann-Matthes
Jun 19, 1997·The New England Journal of Medicine·L C HartmannC G Moertel

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Citations

Dec 7, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Rafiaa ValjiSunita Vohra
Jan 18, 2014·International Immunopharmacology·Fabiana N FonsecaSusanna Cunningham-Rundles
Jul 12, 2008·Molecular Nutrition & Food Research·Camille Freeman, Kevin Spelman
Aug 28, 2015·European Journal of Drug Metabolism and Pharmacokinetics·Enoche F OgaToshiharu Horie
Nov 7, 2006·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·B ClassenC Bodinet
Mar 25, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Youji JiaYanping Yang
Mar 24, 2004·Integrative Cancer Therapies·Keith I Block, Mark N Mead
Nov 13, 2007·Journal of Veterinary Science·Amira M K AbouelellaAhmed M Zahran
May 2, 2013·The Cochrane Database of Systematic Reviews·Jinlin YangYiping Wang
Oct 19, 2019·Biomolecules·Erin DobrangeWim Van den Ende

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