PMID: 46329Feb 1, 1975

Polysaccharides of metaplastic mucosa and carcinoma of the gallbladder

Laboratory Investigation; a Journal of Technical Methods and Pathology
M Laitio, T Terho

Abstract

The polysaccharide composition of the human gallbladder well was studied in carcinomas and metaplastic changes of various degrees, and the results obtained were compared with those for the normal material previously presented (Terho, T., and Laitio, M. Biochim. Biophys. Acta 338: 135, 1974). Elevated amounts of acid connective tissue polysaccharides (heparitin and dermatan sulfates as well as chondroitin 4- or 6-sulfate, or both, could be observed in carinomas. In histochemical stainings it was found that in carcinomas and in the two specimens classified as group III (containing the most extensive metaplastic changes at disposal), the intracellular mucin was mainly neutral or nonsulfated acidic. The amounts of sulfated mucin were relatively insignificant. This mucin polysaccharide material was isolated and its composition was determined. It was observed to be large polysaccharide material was isolated and its composition was determined. It was observed to be large molecular (approximate molecular sizes 1 to 2 times 10-6), and to be composed of fucose, galactose, glucosamine, and galactosamine as well as small amounts of sialic acid. The basic structure of these polysaccharides is thus similar to that of normal sulfated mucin. T...Continue Reading

Related Concepts

Chondroitin
Galactose Measurement
Mucin-1 protein
Glycoproteins
Protoplasm
Gallbladder (Mmhcc)
Sulfomucin
Sialic Acid Assay
Dermatan Sulfate
Galactose

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