PMID: 4150383Dec 1, 1973

Polysaccharides of the genus Bacillus cross-reactive with the capsular polysaccharides of Diplococcus pneumoniae type 3, Haemophilus influenzae type b, and Neisseria meningitidis group A

Infection and Immunity
R L MyerowitzJ B Robbins

Abstract

We studied 174 strains of the genus Bacillus for cross-reacting antigens to the capsular polysaccharides of groups A and C meningococcus, types I and III pneumococcus, and Haemophilus influenzae type b. Cross-reactions were detected by immunodiffusion in agarose gel by using type-specific antisera and confirmed by absorption and inhibition experiments. Of 20 Bacillus pumilis strains, six had an antigen cross-reacting with group A meningococcal polysaccharide. Other cross-reactions included one strain of B. pumilis with H. influenzae type b, one of B. cereus var. mycoides with pneumococcus type III, and one of B. alvei with both type b and SIII polysaccharides. These cross-reacting antigens are polysaccharides of vegetative cells and may be extracellular in location. Because these bacilli have antigens cross-reacting with the virulence factors of pyogenic bacteria, they may, as normal flora, be an antigenic stimulus for "natural" serum anti-capsular antibodies to the type b Haemophilus and group A meningococcus polysaccharides.

Citations

Jun 1, 1978·Acta Pathologica Et Microbiologica Scandinavica. Section C, Immunology·G E Hoff, N Høiby
Sep 1, 1978·CRC Critical Reviews in Microbiology·M Solotorovsky, M Lynn
Oct 7, 2004·Journal of Bacteriology·Joanna Kubler-KielbR Schneerson
Oct 2, 2008·Clinical and Vaccine Immunology : CVI·Caroline L TrotterElizabeth Miller
Mar 6, 2015·The Pediatric Infectious Disease Journal·Kirsten P PerrettJodie McVernon
Feb 22, 2014·Proceedings of the National Academy of Sciences of the United States of America·J B RobbinsJoseph Shiloach
Jul 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·R SchneersonJ B Robbins

Related Concepts

Antigens, Bacterial
Bacillus cereus
Cross Reactions
Immunodiffusion Measurement
Haemophilus influenzae
Neisseria meningitidis
Polysaccharides, Bacterial
Serotyping
Streptococcus pneumoniae
Pathogenicity

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