Polysaccharides-Rich Extract of Ganoderma lucidum (M.A. Curtis:Fr.) P. Karst Accelerates Wound Healing in Streptozotocin-Induced Diabetic Rats

Evidence-based Complementary and Alternative Medicine : ECAM
Poh-Guat ChengUmah Rani Kuppusamy

Abstract

Ganoderma lucidum (M.A. Curtis:Fr.) P. Karst is a popular medicinal mushroom. Scientific reports had shown that the wound healing effects of G. lucidum were partly attributed to its rich polysaccharides. However, little attention has been paid to its potential effects on wounds associated with diabetes mellitus. In this study, we evaluated the wound healing activity of the hot aqueous extract of G. lucidum in streptozotocin-induced diabetic rats. The extract of G. lucidum was standardised based on chemical contents (w/w) of total polysaccharides (25.1%), ganoderic acid A (0.45%), and adenosine (0.069%). Six groups of six rats were experimentally wounded in the posterior neck region. Intrasite gel was used as a positive control and aqueous cream as the placebo. Topical application with 10% (w/w) of mushroom extract-incorporated aqueous cream was more effective than that with Intrasite gel in terms of wound closure. The antioxidant activity in serum of rats treated with aqueous extract of G. lucidum was significantly higher; whereas the oxidative protein products and lipid damage were lower when compared to those of the controls. These findings strongly support the beneficial effects of standardised aqueous extract of G. lucidum ...Continue Reading

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Citations

Dec 31, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Balraj Singh GillSanjeev Kumar
Nov 12, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Zahra A AminMahmood A Abdulla
Mar 21, 2015·Phytochemistry·Haou-Tzong MaShui-Tein Chen
Jul 15, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Mariáurea Matias SarandyReggiani Vilela Gonçalves
Mar 28, 2017·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Fang-Rui CaoQi Chang
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Oct 31, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Aleksandra ShedoevaChen Fan
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Apr 4, 2021·Journal of Fungi·Sariya MapoungPornngarm Limtrakul Dejkriengkraikul

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Methods Mentioned

BETA
light microscopy
MDA
ELISA
amputation

Software Mentioned

Turbochrom

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